Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3378389..3379058 Replicon chromosome
Accession NZ_CP033055
Organism Serratia sp. 3ACOL1

Toxin (Protein)


Gene name cptA Uniprot ID A0A3G2FJN3
Locus tag D9980_RS15205 Protein ID WP_024486356.1
Coordinates 3378389..3378811 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3G2FIP7
Locus tag D9980_RS15210 Protein ID WP_024486357.1
Coordinates 3378792..3379058 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9980_RS15185 3374184..3374702 + 519 WP_021179810.1 flavodoxin FldB -
D9980_RS15190 3374787..3376175 - 1389 WP_121607748.1 cell envelope integrity protein CreD -
D9980_RS15195 3376279..3377697 - 1419 WP_121607749.1 two-component system sensor histidine kinase CreC -
D9980_RS15200 3377694..3378389 - 696 WP_024486355.1 two-component system response regulator CreB -
D9980_RS15205 3378389..3378811 - 423 WP_024486356.1 protein YgfX Toxin
D9980_RS15210 3378792..3379058 - 267 WP_024486357.1 FAD assembly factor SdhE Antitoxin
D9980_RS15215 3379359..3380351 + 993 WP_121609032.1 tRNA-modifying protein YgfZ -
D9980_RS15220 3380391..3380888 - 498 WP_021179803.1 DUF2165 domain-containing protein -
D9980_RS15225 3381121..3381795 - 675 WP_024486360.1 hemolysin III family protein -
D9980_RS15230 3382032..3382640 + 609 WP_121607750.1 HD domain-containing protein -
D9980_RS15235 3382941..3383687 - 747 WP_121607751.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16425.30 Da        Isoelectric Point: 9.9516

>T113012 WP_024486356.1 NZ_CP033055:c3378811-3378389 [Serratia sp. 3ACOL1]
VAQWRCDVRVSWRTQLISLLTHGLLILLILIAPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLAERRIEWHGQ
EWLMVNKPWMPGFGILLSLQQIDGKKRHRLWLASDSMSKADWRQLRQGLLFEQSATDEDV

Download         Length: 423 bp

>T113012 NZ_CP033055:c3378811-3378389 [Serratia sp. 3ACOL1]
GTGGCCCAGTGGCGATGTGATGTCCGCGTTTCCTGGCGTACCCAGTTAATCTCGTTGTTGACTCACGGCCTGCTGATTTT
GCTGATCCTGATCGCCCCGTGGCCGGAAGGCTATGGCCCGATTTGGTTGGTGCTGTTGACGTTGGTGGTGTTTGAGTGCA
TTCGCAGCCAAAAGCGCATTGCATCCAGGCAGGGAGAACTGCGGTTGCTGGCTGAACGCCGGATTGAGTGGCATGGCCAG
GAATGGCTGATGGTGAACAAGCCCTGGATGCCTGGGTTCGGTATTTTACTGTCGCTTCAGCAGATCGACGGCAAGAAACG
CCATCGGCTGTGGTTGGCTTCGGATTCCATGAGCAAAGCGGATTGGCGCCAACTGCGTCAGGGGTTGTTGTTTGAACAAT
CCGCTACCGACGAGGACGTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10342.85 Da        Isoelectric Point: 6.0634

>AT113012 WP_024486357.1 NZ_CP033055:c3379058-3378792 [Serratia sp. 3ACOL1]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDADKAVFIRLLECDDPDLFNWLMNHGAPHDQDLQRMVSLIQTRN
KARGPVAM

Download         Length: 267 bp

>AT113012 NZ_CP033055:c3379058-3378792 [Serratia sp. 3ACOL1]
ATGGATATTAATAATAAAGCACGTATTCACTGGGCCTGCCGCCGCGGCATGCGCGAGTTGGATATCTCGATCATGCCGTT
TTTCGAACATGAATACGATACGCTGAGTGATGCAGACAAGGCCGTATTCATCCGCTTGCTCGAATGTGACGACCCCGATT
TGTTTAACTGGCTGATGAATCATGGCGCTCCGCACGATCAAGATCTGCAGAGAATGGTGTCCCTGATCCAAACGCGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2FJN3

Antitoxin

Source ID Structure
AlphaFold DB A0A3G2FIP7

References