Detailed information of TA system TA113010

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2941708..2942364
• Replicon: chromosome
• Accession: NZ_CP033055
• Organism: Serratia sp. 3ACOL1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D9980_RS13195
• Protein ID: WP_121607532.1
• Coordinates: 2941708..2942097 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U2NVJ4
• Locus tag: D9980_RS13200
• Protein ID: WP_021178792.1
• Coordinates: 2942101..2942364 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D9980_RS13175	2936873..2938318	+	1446	WP_121607531.1	MFS transporter	-
D9980_RS13180	2938367..2939497	-	1131	WP_121609020.1	transposase	-
D9980_RS13185	2939605..2940975	+	1371	WP_065686566.1	two-component system sensor histidine kinase BaeS	-
D9980_RS13190	2940988..2941704	+	717	WP_024486275.1	two-component system response regulator BaeR	-
D9980_RS13195	2941708..2942097	-	390	WP_121607532.1	type II toxin-antitoxin system VapC family toxin	Toxin
D9980_RS13200	2942101..2942364	-	264	WP_021178792.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
D9980_RS13205	2942711..2943049	+	339	WP_024486176.1	YegP family protein	-
D9980_RS13210	2943230..2944582	+	1353	WP_021178794.1	tRNA 5-hydroxyuridine modification protein YegQ	-
D9980_RS13215	2945117..2946016	+	900	WP_121607533.1	lipid kinase YegS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2938367..2939497	1130

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14275.51 Da
• Isoelectric Point: 7.8799

>T113010 WP_121607532.1 NZ_CP033055:c2942097-2941708 [Serratia sp. 3ACOL1]
MYMFDTNTVSQLFRQHPRLLAAMGRVPPSSVCISSITQAELLYGVAKRQNKALKQTVMMFLDAVTVYSWDSAAAHCYGVM
RASMEKQGRPMGALDQLIAAHAVSRGATIVTSDRAFTMVAELEVEDWTQ

Nucleotide

• Length: 390 bp

>T113010 NZ_CP033055:c2942097-2941708 [Serratia sp. 3ACOL1]
ATGTATATGTTCGACACTAACACGGTGAGCCAGCTTTTTCGTCAGCATCCTCGGCTGCTTGCGGCTATGGGCCGGGTACC
GCCATCGTCGGTGTGTATTTCCAGCATAACCCAGGCGGAACTGCTTTATGGCGTCGCCAAGCGGCAGAACAAGGCGCTAA
AACAGACGGTGATGATGTTCCTGGACGCCGTCACCGTTTACTCCTGGGACTCTGCGGCGGCACATTGCTATGGTGTCATG
CGAGCAAGTATGGAAAAACAAGGCAGACCGATGGGGGCGTTGGATCAGCTTATTGCCGCACATGCGGTAAGCCGTGGCGC
AACCATAGTGACCAGCGATCGAGCTTTCACTATGGTCGCGGAGCTTGAGGTGGAAGACTGGACGCAGTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10157.53 Da
• Isoelectric Point: 4.8232

>AT113010 WP_021178792.1 NZ_CP033055:c2942364-2942101 [Serratia sp. 3ACOL1]
MERVAKLFKNGRNQAVRLPVEFEFDVDQVYIRRDEQGNVILSKHPMKLDSWQPLLTMLQNVAVPADFLTADDRQQGVAER
DPFKEEQ

Nucleotide

• Length: 264 bp

>AT113010 NZ_CP033055:c2942364-2942101 [Serratia sp. 3ACOL1]
ATGGAAAGAGTCGCCAAGCTTTTTAAAAACGGTAGAAATCAGGCGGTAAGATTGCCAGTGGAATTCGAATTCGATGTCGA
TCAGGTTTATATTCGCCGGGATGAACAGGGTAACGTTATCTTGTCGAAGCATCCAATGAAATTGGACTCCTGGCAACCGC
TACTGACCATGTTGCAAAACGTGGCGGTTCCTGCTGACTTCCTGACTGCTGACGATCGCCAGCAAGGGGTAGCAGAACGG
GATCCGTTCAAGGAGGAGCAGTAA

Structures

Antitoxin

• AlphaFold DB: U2NVJ4