Detailed information of TA system TA113009

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2108336..2108965
• Replicon: chromosome
• Accession: NZ_CP033055
• Organism: Serratia sp. 3ACOL1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: D9980_RS09695
• Protein ID: WP_121607152.1
• Coordinates: 2108336..2108524 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A1C7WBI8
• Locus tag: D9980_RS09700
• Protein ID: WP_065684215.1
• Coordinates: 2108552..2108965 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D9980_RS09685	2106363..2106992	-	630	WP_071680877.1	TetR/AcrR family transcriptional regulator	-
D9980_RS09690	2107201..2108136	+	936	WP_121607151.1	nitronate monooxygenase	-
D9980_RS09695	2108336..2108524	+	189	WP_121607152.1	type II toxin-antitoxin system HicA family toxin	Toxin
D9980_RS09700	2108552..2108965	+	414	WP_065684215.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
D9980_RS09705	2108998..2109750	-	753	WP_021805696.1	L-cystine ABC transporter ATP-binding protein YecC	-
D9980_RS09710	2109754..2110416	-	663	WP_021180972.1	cystine ABC transporter permease	-
D9980_RS09715	2110416..2111216	-	801	WP_021180971.1	cystine ABC transporter substrate-binding protein	-
D9980_RS09720	2111335..2112321	-	987	WP_024528879.1	D-cysteine desulfhydrase	-
D9980_RS09725	2112516..2113025	-	510	WP_121607153.1	flagella biosynthesis regulatory protein FliZ	-
D9980_RS09730	2113086..2113808	-	723	WP_121607154.1	RNA polymerase sigma factor FliA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fliZ / fliA	2108303..2113808	5505

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7015.20 Da
• Isoelectric Point: 11.1589

>T113009 WP_121607152.1 NZ_CP033055:2108336-2108524 [Serratia sp. 3ACOL1]
VKSSELIKRLESHGWVLQRIKGSHHQFKHPNSPLVITVPHPNKDVKLGTLRQIMKDAGLLNS

Nucleotide

• Length: 189 bp

>T113009 NZ_CP033055:2108336-2108524 [Serratia sp. 3ACOL1]
GTGAAAAGTTCAGAACTGATTAAACGACTCGAAAGCCATGGTTGGGTTTTACAACGGATCAAAGGCAGCCACCATCAATT
CAAACACCCCAACTCACCGTTGGTGATCACCGTGCCTCATCCCAATAAGGATGTGAAATTGGGAACGCTGCGGCAAATCA
TGAAGGATGCAGGGTTGCTTAATTCCTAG

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15017.74 Da
• Isoelectric Point: 4.8403

>AT113009 WP_065684215.1 NZ_CP033055:2108552-2108965 [Serratia sp. 3ACOL1]
MFYPAYIHAEPDGSASGFFPDVPGCYFAGDSLDQTFQDAKSALDAHFELLSEENQAIPRPQAVSFHLAQGNDALNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKAG

Nucleotide

• Length: 414 bp

>AT113009 NZ_CP033055:2108552-2108965 [Serratia sp. 3ACOL1]
ATGTTTTATCCCGCTTATATACATGCCGAGCCCGATGGCAGCGCCAGCGGCTTTTTTCCCGATGTGCCAGGCTGCTACTT
TGCCGGAGACAGTCTCGATCAGACCTTCCAGGATGCCAAAAGCGCGCTGGATGCCCACTTTGAATTATTGAGCGAAGAGA
ATCAGGCCATTCCACGCCCACAAGCAGTGTCCTTCCATCTGGCTCAGGGCAACGACGCCCTTAATGGCGGCCAGTGGTTA
CTGGTGGATATCAATATGGACAAGTTCGATGGCCGGGCAGAACGCATCAATATCACGTTGCCCCACAGGTTGCTCAACCG
TATTGATTCGTTGGTGCAGCAGCACCCGGGTTATGGCAGCCGCAGCGCATTTCTCGCCGCCGCAGCGCGTAATGAGTTGT
TAAAGGCAGGATAA

Structures

Antitoxin

• AlphaFold DB: A0A1C7WBI8