Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3271605..3272203 Replicon chromosome
Accession NZ_CP033048
Organism Virgibacillus sp. Bac330

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag D9780_RS15250 Protein ID WP_121640673.1
Coordinates 3271605..3271934 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag D9780_RS15255 Protein ID WP_121640674.1
Coordinates 3271934..3272203 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9780_RS15220 3266868..3267431 - 564 WP_121640667.1 GNAT family N-acetyltransferase -
D9780_RS15225 3267738..3268367 + 630 WP_121640668.1 VOC family protein -
D9780_RS15230 3268743..3269063 - 321 WP_121640669.1 thioredoxin family protein -
D9780_RS15235 3269132..3269944 - 813 WP_121640670.1 DUF368 domain-containing protein -
D9780_RS15240 3270259..3270585 + 327 WP_121640671.1 PadR family transcriptional regulator -
D9780_RS15245 3270591..3271280 + 690 WP_121640672.1 DUF1129 family protein -
D9780_RS15250 3271605..3271934 - 330 WP_121640673.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
D9780_RS15255 3271934..3272203 - 270 WP_121640674.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D9780_RS15260 3272925..3273125 + 201 WP_116278388.1 hypothetical protein -
D9780_RS15270 3273823..3274236 - 414 WP_121640675.1 GNAT family N-acetyltransferase -
D9780_RS15275 3274598..3275749 - 1152 WP_121640676.1 CapA family protein -
D9780_RS15280 3275958..3276116 + 159 WP_116278384.1 YfhE family protein -
D9780_RS15285 3276238..3277155 + 918 WP_121640677.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-100)

Antitoxin

SpoVT-AbrB domain

(16-60)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11978.86 Da        Isoelectric Point: 4.7961

>T112994 WP_121640673.1 NZ_CP033048:c3271934-3271605 [Virgibacillus sp. Bac330]
MEIPDKGDLILLNISPQSGHEQAGYRPALVLSPKTFNGASFLMACPITSKEKGYPFEVKIPDGLNINGVILTDQLRSLDW
RARGLKIVDRAPTETVEECIDLISTILVN

Download         Length: 330 bp

>T112994 NZ_CP033048:c3271934-3271605 [Virgibacillus sp. Bac330]
ATGGAAATACCAGACAAAGGAGATTTGATTTTACTAAATATCAGTCCGCAATCAGGTCACGAACAGGCAGGGTATCGACC
AGCTTTGGTTCTGTCACCAAAAACATTTAATGGAGCATCTTTTTTAATGGCTTGCCCCATCACATCCAAAGAAAAAGGGT
ATCCATTTGAAGTTAAAATTCCGGATGGGTTGAACATAAATGGCGTGATTCTGACGGATCAGCTCAGAAGTTTGGATTGG
CGTGCCAGGGGTTTAAAAATAGTAGATAGAGCACCCACTGAAACGGTCGAAGAATGTATAGATTTGATTTCAACAATTTT
AGTCAATTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10057.58 Da        Isoelectric Point: 10.1404

>AT112994 WP_121640674.1 NZ_CP033048:c3272203-3271934 [Virgibacillus sp. Bac330]
MTKNSKGGVRVTTKVQKWGNSLAVRIPSNMADEIKIVQGTEVELRVENRELKIVPAKKKQTLEELMAKITSENRHDEIDW
GKAEGAEIR

Download         Length: 270 bp

>AT112994 NZ_CP033048:c3272203-3271934 [Virgibacillus sp. Bac330]
ATGACAAAGAATAGTAAAGGAGGGGTTCGTGTGACGACAAAAGTTCAAAAGTGGGGAAATAGTCTTGCCGTTAGAATACC
TTCCAATATGGCAGACGAAATAAAAATAGTCCAAGGCACCGAAGTAGAGCTTAGGGTTGAAAATAGAGAACTTAAAATTG
TACCAGCAAAGAAGAAACAAACACTGGAAGAATTGATGGCGAAGATAACGTCTGAAAATCGCCACGATGAGATTGATTGG
GGGAAAGCCGAAGGAGCTGAGATTCGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References