Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel2-ATphRel2/DUF4065(antitoxin)
Location 938036..939504 Replicon chromosome
Accession NZ_CP033048
Organism Virgibacillus sp. Bac330

Toxin (Protein)


Gene name phRel2 Uniprot ID -
Locus tag D9780_RS04195 Protein ID WP_162985784.1
Coordinates 938036..938740 (+) Length 235 a.a.

Antitoxin (Protein)


Gene name ATphRel2 Uniprot ID -
Locus tag D9780_RS04200 Protein ID WP_121639391.1
Coordinates 938755..939504 (+) Length 250 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9780_RS04175 933083..933364 + 282 WP_121639388.1 ketopantoate hydroxymethyltransferase -
D9780_RS20965 934147..934449 + 303 Protein_816 phage baseplate upper protein -
D9780_RS20970 935870..936007 + 138 WP_162985783.1 hypothetical protein -
D9780_RS04185 936094..936525 + 432 WP_121641425.1 phage holin family protein -
D9780_RS04190 936582..937658 + 1077 WP_121639389.1 N-acetylmuramoyl-L-alanine amidase -
D9780_RS04195 938036..938740 + 705 WP_162985784.1 hypothetical protein Toxin
D9780_RS04200 938755..939504 + 750 WP_121639391.1 DUF4065 domain-containing protein Antitoxin
D9780_RS04205 939532..939717 - 186 WP_121639392.1 hypothetical protein -
D9780_RS04210 939852..940067 + 216 WP_121639393.1 hypothetical protein -
D9780_RS04215 940067..940381 + 315 WP_121639394.1 YolD-like family protein -
D9780_RS04220 941835..942290 + 456 WP_121641426.1 HNH/ENDO VII family nuclease -
D9780_RS04225 942305..942754 + 450 WP_121639395.1 SMI1/KNR4 family protein -
D9780_RS04230 943668..944117 + 450 WP_205601130.1 MepB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 889610..940381 50771


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(113-225)


Sequences

Toxin        


Download         Length: 235 a.a.        Molecular weight: 27872.06 Da        Isoelectric Point: 7.9753

>T112992 WP_162985784.1 NZ_CP033048:938036-938740 [Virgibacillus sp. Bac330]
MNTAKDKIIANNSIVEYDIEIIEEIIHEIINLHQKFSYMYGNLCSLNLKRNKIRDVVSIMDNNSYLINNNFLSIVYNYLE
ELKMLIVDIDLEERYKHLDFRPRTKDPESVFYKIGHYFAKAGKGTYSINKCLNDLLGFRICIKNFDHKCSIFYTLCDYIK
EEDYNIKCIDSSKGDYKATHIYIKGPSNKFFPWELQVWNLDDREVNYESHKMHKQMYKKSAEIHKNGFTIVKRP

Download         Length: 705 bp

>T112992 NZ_CP033048:938036-938740 [Virgibacillus sp. Bac330]
ATGAATACTGCTAAAGATAAAATAATAGCAAATAACAGCATTGTTGAATATGATATCGAGATAATCGAAGAGATAATTCA
TGAAATAATAAATCTACACCAGAAATTTTCATATATGTATGGGAATCTGTGTAGTTTAAACCTTAAACGAAATAAGATAA
GGGATGTAGTTAGCATAATGGATAACAATAGTTATCTTATAAACAATAACTTCCTTTCAATTGTCTATAATTATTTAGAA
GAGCTAAAAATGTTAATAGTAGATATAGACTTAGAGGAAAGATACAAACATTTGGATTTTAGACCGAGAACAAAAGATCC
TGAAAGTGTTTTTTATAAAATAGGGCATTATTTTGCGAAAGCTGGAAAAGGTACCTATTCAATTAATAAATGTCTAAATG
ATTTACTTGGGTTTCGAATATGTATAAAAAACTTTGACCATAAGTGCAGTATATTTTATACTTTATGTGACTATATTAAA
GAAGAGGATTATAATATAAAATGTATAGACTCATCAAAAGGTGATTATAAAGCTACACACATATATATTAAAGGGCCAAG
TAATAAGTTCTTTCCATGGGAACTGCAAGTATGGAATTTAGACGATAGAGAAGTAAATTATGAATCACATAAAATGCATA
AACAGATGTATAAAAAGTCTGCTGAAATACATAAAAATGGATTTACAATAGTTAAACGACCTTGA

Antitoxin


Download         Length: 250 a.a.        Molecular weight: 28724.89 Da        Isoelectric Point: 6.3003

>AT112992 WP_121639391.1 NZ_CP033048:938755-939504 [Virgibacillus sp. Bac330]
MAYHFLAITSSYSKGYRIGWNYSSEDTLDKAVIKRFLTKMKKRCGDVQFGIHKITTNSLSISSVKEKDMFFEDVVFTSDM
DQFISLVASDQKLSALDISKFVLTMLPMSHIKLQKILYYTYAEFLKRTGEKLFKEPIVSYKYGPVVESVFREFTEHGALI
IDYEEDENFVIVADDVATTPSFIKVISSEHGSTVIDCVMDTLQRYGDEKPFNLVDKTHRVGGPWQRVYEPSQNNIITDDL
ILQYHHFVK

Download         Length: 750 bp

>AT112992 NZ_CP033048:938755-939504 [Virgibacillus sp. Bac330]
ATGGCTTATCACTTTTTAGCGATAACAAGCTCGTACTCTAAAGGCTATAGAATTGGTTGGAATTATTCTTCTGAGGATAC
ATTAGATAAGGCAGTGATTAAAAGATTTTTAACAAAGATGAAAAAAAGATGCGGGGATGTTCAATTCGGCATCCATAAAA
TTACTACTAATTCTTTATCCATTTCCTCAGTTAAAGAAAAGGATATGTTCTTTGAGGACGTTGTTTTTACCAGTGATATG
GATCAGTTCATTTCCCTTGTAGCGAGTGATCAGAAATTATCAGCTCTAGATATTTCCAAATTTGTTTTAACTATGTTGCC
AATGTCACACATAAAATTACAAAAGATTCTATATTACACGTATGCAGAATTCCTAAAAAGAACCGGGGAAAAATTATTTA
AAGAACCAATCGTTTCTTATAAATATGGACCGGTTGTAGAGAGCGTTTTTAGAGAGTTCACTGAGCACGGTGCATTAATT
ATTGATTACGAAGAAGATGAAAACTTTGTAATAGTCGCTGATGATGTAGCAACTACACCTTCATTCATCAAGGTTATTTC
CTCAGAGCATGGTTCAACTGTGATTGATTGTGTAATGGATACTTTACAGAGATATGGTGATGAAAAACCATTTAATTTAG
TTGATAAAACTCACAGGGTAGGTGGTCCTTGGCAAAGGGTTTATGAACCAAGCCAAAACAACATAATTACTGATGATCTT
ATATTACAATATCATCATTTTGTAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References