112991

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 1823033..1823681 Replicon chromosome
Accession NZ_CP033046
Organism Virgibacillus sp. Bac332

Toxin (Protein)


Gene name mazF Uniprot ID A0A941IBB0
Locus tag D9782_RS08730 Protein ID WP_026680359.1
Coordinates 1823322..1823681 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag D9782_RS08725 Protein ID WP_121605854.1
Coordinates 1823033..1823317 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9782_RS08705 1818282..1818641 + 360 WP_026680354.1 holo-ACP synthase -
D9782_RS08710 1818701..1820212 + 1512 WP_121604537.1 NAD(P)H-hydrate dehydratase -
D9782_RS08715 1820270..1821286 + 1017 WP_026680356.1 outer membrane lipoprotein carrier protein LolA -
D9782_RS08720 1821732..1822850 + 1119 WP_121604538.1 alanine racemase -
D9782_RS08725 1823033..1823317 + 285 WP_121605854.1 antitoxin Antitoxin
D9782_RS08730 1823322..1823681 + 360 WP_026680359.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
D9782_RS08735 1823999..1824868 + 870 WP_026680360.1 RsbT co-antagonist protein RsbRA -
D9782_RS08740 1824865..1825230 + 366 WP_200862543.1 STAS domain-containing protein -
D9782_RS08745 1825236..1825637 + 402 WP_026680362.1 anti-sigma regulatory factor -
D9782_RS08750 1825921..1826934 + 1014 WP_026680363.1 PP2C family protein-serine/threonine phosphatase -
D9782_RS08755 1827032..1827364 + 333 WP_026680364.1 STAS domain-containing protein -
D9782_RS08760 1827364..1827840 + 477 WP_121604539.1 anti-sigma B factor RsbW -
D9782_RS08765 1827812..1828603 + 792 WP_026680366.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13368.57 Da        Isoelectric Point: 9.4865

>T112991 WP_026680359.1 NZ_CP033046:1823322-1823681 [Virgibacillus sp. Bac332]
MIVQRGEVYFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKRYGFDRDSVILLEQI
RTLDKQRLTDKITKLDKEMMNKINQALEISLGLKDMYGQ

Download         Length: 360 bp

>T112991 NZ_CP033046:1823322-1823681 [Virgibacillus sp. Bac332]
TTGATCGTACAAAGAGGCGAAGTATATTTCGCTGACCTTTCCCCTGTTGTTGGATCAGAGCAGGGAGGCGTGCGCCCGGT
ATTGATCCTGCAAAATGATATCGGGAATCGTTTCAGTCCTACCGTTATTGTCGCAGCAATTACAGCACAAATTCAGAAAG
CGAAGCTCCCAACGCATGTGGAGATTAACGCAAAACGTTATGGATTTGATCGGGATTCCGTTATTTTGCTAGAACAAATT
AGAACGCTTGATAAACAACGATTAACAGATAAAATAACAAAGTTAGATAAAGAAATGATGAATAAGATTAACCAAGCATT
AGAAATCAGTCTAGGGCTGAAAGATATGTATGGTCAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10880.26 Da        Isoelectric Point: 4.4498

>AT112991 WP_121605854.1 NZ_CP033046:1823033-1823317 [Virgibacillus sp. Bac332]
MSESLQEVLVKIPKNLLNEVDGLMKYENSDLSDFICQATRSYLQHKRDEHIQQFRETMQRGYEEMGLINLTIASEAFQAE
EEAKNTLERSVIGV

Download         Length: 285 bp

>AT112991 NZ_CP033046:1823033-1823317 [Virgibacillus sp. Bac332]
TTGTCAGAGAGCTTACAAGAAGTATTAGTTAAGATACCGAAAAACCTGTTAAATGAGGTGGATGGTCTAATGAAATATGA
GAATAGTGATTTAAGTGATTTCATTTGTCAGGCAACTAGAAGCTATCTTCAACACAAAAGAGATGAGCATATCCAACAAT
TTCGTGAAACGATGCAACGAGGCTATGAAGAAATGGGCCTCATTAATTTAACAATTGCTTCAGAAGCTTTTCAAGCTGAA
GAGGAGGCAAAAAATACCTTGGAACGCTCTGTGATCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References