112990

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 1352752..1353388 Replicon chromosome
Accession NZ_CP033044
Organism Mesobacillus foraminis strain Bac44

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag D9829_RS06575 Protein ID WP_121610243.1
Coordinates 1352752..1353102 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag D9829_RS06580 Protein ID WP_121613820.1
Coordinates 1353107..1353388 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9829_RS06540 1348153..1348947 - 795 WP_121610236.1 RNA polymerase sigma factor SigB -
D9829_RS06545 1348925..1349398 - 474 WP_121610237.1 anti-sigma B factor RsbW -
D9829_RS06550 1349398..1349727 - 330 WP_121610238.1 anti-sigma factor antagonist -
D9829_RS06555 1349788..1350798 - 1011 WP_121610239.1 PP2C family protein-serine/threonine phosphatase -
D9829_RS06560 1350811..1351212 - 402 WP_121610240.1 anti-sigma regulatory factor -
D9829_RS06565 1351217..1351573 - 357 WP_121610241.1 STAS domain-containing protein -
D9829_RS06570 1351570..1352406 - 837 WP_121610242.1 STAS domain-containing protein -
D9829_RS06575 1352752..1353102 - 351 WP_121610243.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
D9829_RS06580 1353107..1353388 - 282 WP_121613820.1 antitoxin endoai Antitoxin
D9829_RS06585 1353571..1354734 - 1164 WP_121610244.1 alanine racemase -
D9829_RS06590 1354870..1355883 - 1014 WP_121610245.1 outer membrane lipoprotein carrier protein LolA -
D9829_RS06595 1356036..1356398 - 363 WP_121610246.1 holo-ACP synthase -
D9829_RS06600 1356587..1357174 + 588 WP_121610247.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12962.02 Da        Isoelectric Point: 5.1663

>T112990 WP_121610243.1 NZ_CP033044:c1353102-1352752 [Mesobacillus foraminis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMGKVDEALQISLGLIEF

Download         Length: 351 bp

>T112990 NZ_CP033044:c1353102-1352752 [Mesobacillus foraminis]
TTGATTGTCAAACGTGGTGACGTTTATTTTGCGGACCTATCCCCAGTTGTTGGTTCTGAACAAGGCGGCGTCCGCCCTGT
ACTTGTCATCCAAAACGACATCGGGAATCGGTTTAGTCCCACAGTAATTATTGCAGCCATTACCGCGCAGATCCAAAAAG
CGAAGCTGCCAACGCATGTTGAAATTGATGCGAAGCGTTACGGTTTTGAACGAGACTCGGTCATATTATTGGAACAAATT
CGTACAATTGACAAACAGCGCCTAACCGATAAGATTACCCATCTCGATGACGAAATGATGGGGAAAGTGGATGAAGCCCT
TCAGATAAGTTTAGGCCTTATTGAATTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10799.33 Da        Isoelectric Point: 7.2025

>AT112990 WP_121613820.1 NZ_CP033044:c1353388-1353107 [Mesobacillus foraminis]
VSESSATTEILVKLPQHLLMELDGFAKQENVNRSEFIYQATKMYLRDRKKRQIRESMRRGYMEMAKINLTIASEAFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp

>AT112990 NZ_CP033044:c1353388-1353107 [Mesobacillus foraminis]
GTGTCTGAATCCAGCGCAACAACTGAGATCTTGGTGAAGTTACCGCAGCATCTATTGATGGAACTAGATGGCTTTGCAAA
ACAGGAGAACGTCAACCGAAGTGAATTCATTTATCAGGCAACTAAAATGTACTTGCGCGATAGGAAAAAGAGACAAATTC
GCGAATCGATGAGACGCGGCTATATGGAAATGGCCAAAATCAACCTAACGATTGCATCAGAAGCATTTCAGGCAGAATAC
GAGGCAGAACACACAGTCGAACGTTTAGTTAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References