Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 4381958..4382594 Replicon chromosome
Accession NZ_CP033043
Organism Metabacillus litoralis strain Bac94

Toxin (Protein)


Gene name mazF Uniprot ID A0A0M2PN83
Locus tag D9842_RS21470 Protein ID WP_026562078.1
Coordinates 4382244..4382594 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag D9842_RS21465 Protein ID WP_098797598.1
Coordinates 4381958..4382239 (+) Length 94 a.a.

Genomic Context

D9842_RS21450D9842_RS21455D9842_RS21460D9842_RS21465D9842_RS21470D9842_RS21475D9842_RS21480D9842_RS21485D9842_RS21490D9842_RS21495D9842_RS21500D9842_RS21505D9842_RS21445
Location: 4378536..4378901 (366 bp)
Type: Others
Protein ID: WP_121664240.1
Location: 4379117..4380136 (1020 bp)
Type: Others
Protein ID: WP_121664241.1
Location: 4380402..4381547 (1146 bp)
Type: Others
Protein ID: WP_121664242.1
Location: 4381958..4382239 (282 bp)
Type: Antitoxin
Protein ID: WP_098797598.1
Location: 4382244..4382594 (351 bp)
Type: Toxin
Protein ID: WP_026562078.1
Location: 4382946..4383776 (831 bp)
Type: Others
Protein ID: WP_121664243.1
Location: 4383780..4384142 (363 bp)
Type: Others
Protein ID: WP_098797600.1
Location: 4384146..4384547 (402 bp)
Type: Others
Protein ID: WP_098797601.1
Location: 4384558..4385565 (1008 bp)
Type: Others
Protein ID: WP_121664244.1
Location: 4385621..4385953 (333 bp)
Type: Others
Protein ID: WP_121664245.1
Location: 4385950..4386432 (483 bp)
Type: Others
Protein ID: WP_121664246.1
Location: 4386398..4387189 (792 bp)
Type: Others
Protein ID: WP_121664247.1
Location: 4377683..4378402 (720 bp)
Type: Others
Protein ID: WP_121664239.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
D9842_RS214454377683..4378402-720WP_121664239.1rhomboid family intramembrane serine protease-
D9842_RS214504378536..4378901+366WP_121664240.1holo-ACP synthase-
D9842_RS214554379117..4380136+1020WP_121664241.1outer membrane lipoprotein carrier protein LolA-
D9842_RS214604380402..4381547+1146WP_121664242.1alanine racemase-
D9842_RS214654381958..4382239+282WP_098797598.1antitoxin endoaiAntitoxin
D9842_RS214704382244..4382594+351WP_026562078.1type II toxin-antitoxin system endoribonuclease NdoAToxin
D9842_RS214754382946..4383776+831WP_121664243.1STAS domain-containing protein-
D9842_RS214804383780..4384142+363WP_098797600.1STAS domain-containing protein-
D9842_RS214854384146..4384547+402WP_098797601.1anti-sigma regulatory factor-
D9842_RS214904384558..4385565+1008WP_121664244.1PP2C family protein-serine/threonine phosphatase-
D9842_RS214954385621..4385953+333WP_121664245.1anti-sigma factor antagonist-
D9842_RS215004385950..4386432+483WP_121664246.1anti-sigma B factor RsbW-
D9842_RS215054386398..4387189+792WP_121664247.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13020.06 Da        Isoelectric Point: 4.8781

>T112989 WP_026562078.1 NZ_CP033043:4382244-4382594 [Metabacillus litoralis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T112989 NZ_CP033043:4382244-4382594 [Metabacillus litoralis]
TTGATTGTTAAACGAGGCGACGTTTATTTTGCCGATCTTTCTCCAGTTGTAGGTTCAGAGCAAGGTGGCGTACGTCCTGT
ATTAATTATTCAAAACGATATTGGGAACCGCTTTAGTCCTACAGTTATTATAGCGGCAATTACGGCCCAAATTCAAAAAG
CAAAATTGCCAACTCATGTTGAGATTGATGCTAAGCGTTACGGGTTTGAAAGGGATTCGGTTATCCTGCTTGAACAGATT
CGAACGATTGATAAACAAAGGCTTACTGATAAAATTACCCATCTTGATGATGAGATGATGGATAAAGTTGATGAAGCCTT
ACAAATAAGCTTAGGACTTATCGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10598.08 Da        Isoelectric Point: 5.8851

>AT112989 WP_098797598.1 NZ_CP033043:4381958-4382239 [Metabacillus litoralis]
VSESSATTEILIQLPQALVSELDVLVKQENGNRNELIYQATKMYIRERKKRQIRESMRRGYMEMAKINLNIASEAFLAES
EADHTVERLVSGG

Download         Length: 282 bp

>AT112989 NZ_CP033043:4381958-4382239 [Metabacillus litoralis]
GTGTCTGAATCCAGCGCAACAACAGAAATTTTAATTCAGTTACCTCAAGCATTAGTATCAGAATTGGATGTATTGGTAAA
ACAAGAGAACGGGAACAGAAACGAGCTTATTTATCAAGCGACAAAAATGTATATTCGTGAGCGTAAAAAGCGCCAAATTC
GTGAGTCTATGAGACGTGGTTACATGGAAATGGCAAAAATCAATTTGAATATTGCATCTGAAGCATTTTTGGCAGAATCT
GAGGCTGACCATACCGTTGAACGCTTAGTCAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0M2PN83

Antitoxin

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Source
ID
Structure
No matching records found

References