Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1130961..1131454 Replicon chromosome
Accession NZ_CP033041
Organism Enterococcus faecium strain Enterococcus faecium JE1

Toxin (Protein)


Gene name relE Uniprot ID J6KIM0
Locus tag D9Z05_RS05750 Protein ID WP_002400299.1
Coordinates 1131188..1131454 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4Y3JLV3
Locus tag D9Z05_RS05745 Protein ID WP_025478324.1
Coordinates 1130961..1131191 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9Z05_RS05715 1127210..1127977 + 768 WP_002400309.1 MurR/RpiR family transcriptional regulator -
D9Z05_RS05720 1127978..1128421 + 444 WP_002400306.1 hypothetical protein -
D9Z05_RS05725 1128630..1129220 - 591 WP_002400305.1 glutamine amidotransferase -
D9Z05_RS05730 1129833..1130135 + 303 Protein_1081 hypothetical protein -
D9Z05_RS14205 1130315..1130470 + 156 WP_002400302.1 hypothetical protein -
D9Z05_RS05745 1130961..1131191 + 231 WP_025478324.1 hypothetical protein Antitoxin
D9Z05_RS05750 1131188..1131454 + 267 WP_002400299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D9Z05_RS05755 1131705..1131933 + 229 Protein_1085 hypothetical protein -
D9Z05_RS05760 1131949..1133115 + 1167 WP_002314829.1 oxygen-independent coproporphyrinogen III oxidase -
D9Z05_RS05765 1133349..1134392 + 1044 WP_002294449.1 heat-inducible transcriptional repressor HrcA -
D9Z05_RS05770 1134486..1135049 + 564 WP_002400298.1 nucleotide exchange factor GrpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10642.41 Da        Isoelectric Point: 10.4982

>T112988 WP_002400299.1 NZ_CP033041:1131188-1131454 [Enterococcus faecium]
MTYRLEFTPEIQKQLRKMDKHQAMLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDKQLVVIAIQV
GHRRNIYD

Download         Length: 267 bp

>T112988 NZ_CP033041:1131188-1131454 [Enterococcus faecium]
ATGACCTACCGTTTAGAATTCACGCCTGAAATTCAGAAACAACTTCGTAAAATGGACAAGCATCAAGCGATGCTGATCGT
TCGATGGCTGTATCAACATATTGATGGTATTGACGATCCGAGAAAATTCGGAAAAGGATTGACCGCTAATCGTTCAGGAC
AATGGCGTTATCGAATTGGCAAATATCGTGTGTTGGTAGAGATAGAAGATAAACAATTGGTTGTTATCGCTATTCAAGTA
GGACACCGAAGAAATATCTATGATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8790.97 Da        Isoelectric Point: 4.4723

>AT112988 WP_025478324.1 NZ_CP033041:1130961-1131191 [Enterococcus faecium]
MAMITVRVSDAEKEWLSYMAKFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLG

Download         Length: 231 bp

>AT112988 NZ_CP033041:1130961-1131191 [Enterococcus faecium]
ATGGCTATGATTACGGTTCGTGTGAGTGATGCCGAAAAAGAATGGCTTTCTTATATGGCGAAATTTTATGGGATTACTTT
ATCTGAGCTTCTAAAAACCTATTCGATGGAACAACTAGAAGATGAATACGATCGTCAAACGGCTGAAATTGCCCATAAAC
ATTGGGTAGAAAGTGGAAAAACAACAGTATCTATGGAAGAAATCCTTCATGAATTTGGAGGGCTGGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y3JQ03

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y3JLV3

References