Detailed information of TA system TA112987

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1826201..1826837
• Replicon: chromosome
• Accession: NZ_CP033040
• Organism: Thiomicrorhabdus indica strain 13-15A

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D9T12_RS07970
• Protein ID: WP_130537673.1
• Coordinates: 1826436..1826837 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: D9T12_RS07965
• Protein ID: WP_130537672.1
• Coordinates: 1826201..1826443 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D9T12_RS07940	1821550..1823178	+	1629	WP_130537667.1	ParB N-terminal domain-containing protein	-
D9T12_RS07945	1823171..1823758	+	588	WP_130537668.1	DUF2857 family protein	-
D9T12_RS07950	1823761..1824642	+	882	WP_165395065.1	replication initiator protein A	-
D9T12_RS07955	1825535..1825777	+	243	WP_130537670.1	hypothetical protein	-
D9T12_RS07960	1825793..1826101	+	309	WP_130537671.1	hypothetical protein	-
D9T12_RS07965	1826201..1826443	+	243	WP_130537672.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
D9T12_RS07970	1826436..1826837	+	402	WP_130537673.1	type II toxin-antitoxin system VapC family toxin	Toxin
D9T12_RS07975	1826944..1827555	+	612	WP_130537674.1	hypothetical protein	-
D9T12_RS07980	1827911..1828096	+	186	WP_130537675.1	hypothetical protein	-
D9T12_RS07985	1828270..1828917	-	648	WP_130537676.1	hypothetical protein	-
D9T12_RS07990	1828910..1830004	-	1095	WP_206199084.1	AAA family ATPase	-
D9T12_RS07995	1830034..1830582	-	549	WP_130537678.1	recombinase family protein	-
D9T12_RS08000	1830839..1831117	-	279	WP_130537679.1	hypothetical protein	-
D9T12_RS08005	1831107..1831802	-	696	WP_130537680.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1820621..1890408	69787

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14975.22 Da
• Isoelectric Point: 7.0389

>T112987 WP_130537673.1 NZ_CP033040:1826436-1826837 [Thiomicrorhabdus indica]
MIKYLLDTNICIYVIKRRPIEVLQKFNDAAGHMAISSITLAELLHGVEKSQHVARNLKAVEDFCSRLDVIDYDDKAAAHY
GEIRADLENKGKTIGVNDLHIAGHARSLGAILVSNNLKEFERVDGLRFQNWIC

Nucleotide

• Length: 402 bp

>T112987 NZ_CP033040:1826436-1826837 [Thiomicrorhabdus indica]
ATGATTAAGTATTTACTGGACACCAATATTTGCATTTATGTCATCAAACGTAGACCTATAGAGGTTCTTCAGAAGTTTAA
TGATGCAGCTGGCCATATGGCAATTTCTTCTATTACTCTTGCTGAACTTTTGCATGGTGTTGAAAAAAGTCAACATGTAG
CAAGAAATTTAAAAGCAGTTGAAGACTTTTGCAGTCGATTAGATGTCATAGACTATGACGATAAAGCAGCGGCGCATTAC
GGTGAAATTCGTGCAGATCTAGAAAACAAAGGTAAAACGATTGGTGTAAATGATTTGCATATAGCTGGCCATGCAAGGAG
TCTTGGCGCTATCCTCGTTAGCAATAACTTAAAAGAATTTGAGCGTGTCGATGGTTTAAGGTTTCAAAACTGGATTTGTT
GA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9224.33 Da
• Isoelectric Point: 4.4367

>AT112987 WP_130537672.1 NZ_CP033040:1826201-1826443 [Thiomicrorhabdus indica]
MINATVFENNKTQAIRLPVPVRFPRSVKKVVVRAIGQERIISPIENTWDSFFLNPENTASDDFLDERAEQTEALRESFDD

Nucleotide

• Length: 243 bp

>AT112987 NZ_CP033040:1826201-1826443 [Thiomicrorhabdus indica]
ATGATTAATGCGACCGTTTTCGAAAATAATAAAACACAAGCCATTCGTCTTCCTGTTCCTGTTCGCTTTCCTCGTTCAGT
AAAAAAAGTGGTTGTCCGTGCAATTGGCCAAGAGCGGATTATTAGTCCAATAGAAAACACATGGGACAGTTTCTTTTTAA
ATCCAGAAAATACGGCTTCTGATGACTTTTTGGATGAACGTGCTGAGCAAACAGAAGCTTTAAGAGAGTCATTCGATGAT
TAA