Detailed information of TA system TA112983

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 466914..467458
• Replicon: chromosome
• Accession: NZ_CP033034
• Organism: Agrobacterium fabrum strain 12D13

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: At12D13_RS02320
• Protein ID: WP_174047366.1
• Coordinates: 467168..467458 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A7I0REI2
• Locus tag: At12D13_RS02315
• Protein ID: WP_006309847.1
• Coordinates: 466914..467165 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
At12D13_RS02285	462680..463360	+	681	WP_010971151.1	GntR family transcriptional regulator	-
At12D13_RS02290	463406..463870	+	465	WP_121690930.1	DUF1284 domain-containing protein	-
At12D13_RS02295	464054..465154	-	1101	WP_121690017.1	hypothetical protein	-
At12D13_RS02305	465391..466536	+	1146	WP_121690018.1	site-specific DNA-methyltransferase	-
At12D13_RS02310	466688..466924	-	237	WP_121690931.1	hypothetical protein	-
At12D13_RS02315	466914..467165	+	252	WP_006309847.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
At12D13_RS02320	467168..467458	+	291	WP_174047366.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
At12D13_RS02325	467492..468103	-	612	WP_121690020.1	HAD family phosphatase	-
At12D13_RS02330	468100..469203	-	1104	WP_121690021.1	A/G-specific adenine glycosylase	-
At12D13_RS02335	469302..469829	+	528	WP_121690022.1	DUF721 domain-containing protein	-
At12D13_RS02340	469958..470638	+	681	WP_006309853.1	DsbA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (3-63)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11220.89 Da
• Isoelectric Point: 5.6017

>T112983 WP_174047366.1 NZ_CP033034:467168-467458 [Agrobacterium fabrum]
MGFRLSLLAEEDVIRIAEEGILIFGAKQAQKYHRELFAIFELISCSPRMARERDELSPPLRIQRFKAHLVVYSVDADDEV
FIVRVRHGHEDWVNEP

Nucleotide

• Length: 291 bp

>T112983 NZ_CP033034:467168-467458 [Agrobacterium fabrum]
ATGGGTTTTCGTCTGTCTCTGCTCGCGGAAGAGGACGTCATTCGTATTGCGGAGGAGGGCATCCTGATATTCGGGGCCAA
ACAGGCACAGAAATATCATCGGGAACTCTTCGCTATCTTCGAATTGATATCGTGTAGTCCGCGAATGGCGCGCGAACGGG
ACGAATTGTCGCCGCCGCTGCGCATTCAACGCTTCAAGGCGCATCTGGTTGTCTATAGCGTCGACGCGGACGACGAAGTG
TTTATCGTCCGCGTGCGTCATGGGCATGAGGACTGGGTGAATGAACCCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9327.47 Da
• Isoelectric Point: 4.8537

>AT112983 WP_006309847.1 NZ_CP033034:466914-467165 [Agrobacterium fabrum]
MVTMNISLPEPMKEWVEAQSKTGRYSNASDYVRDLIRRDQERGEKIAAMQRLVDEGLQSGIGDRSPEALFAEAEARSAKR
DIG

Nucleotide

• Length: 252 bp

>AT112983 NZ_CP033034:466914-467165 [Agrobacterium fabrum]
ATGGTGACCATGAACATATCGTTGCCCGAGCCGATGAAAGAATGGGTCGAAGCCCAGTCGAAAACTGGTCGTTACTCCAA
TGCCAGCGACTATGTGCGTGATCTCATCCGCAGGGATCAGGAACGGGGCGAAAAGATAGCCGCGATGCAGCGCCTGGTGG
ATGAAGGATTGCAGAGCGGCATCGGTGATCGCTCGCCGGAGGCATTGTTCGCCGAGGCCGAGGCCCGGTCAGCGAAACGC
GATATCGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7I0REI2