Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 622904..623529 Replicon chromosome
Accession NZ_CP033022
Organism Agrobacterium fabrum strain 1D132

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag At1D132_RS03265 Protein ID WP_121651515.1
Coordinates 623170..623529 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag At1D132_RS03260 Protein ID WP_092770440.1
Coordinates 622904..623170 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
At1D132_RS03235 617929..618753 + 825 WP_010971264.1 class D beta-lactamase -
At1D132_RS03240 618793..619401 + 609 WP_121650519.1 class I SAM-dependent methyltransferase -
At1D132_RS03245 619577..622162 + 2586 WP_162992248.1 heavy metal translocating P-type ATPase -
At1D132_RS03250 622159..622581 + 423 WP_006311241.1 Cu(I)-responsive transcriptional regulator -
At1D132_RS03255 622634..622834 + 201 WP_121650520.1 heavy-metal-associated domain-containing protein -
At1D132_RS03260 622904..623170 + 267 WP_092770440.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
At1D132_RS03265 623170..623529 + 360 WP_121651515.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
At1D132_RS27125 623537..623785 - 249 WP_162992249.1 hypothetical protein -
At1D132_RS03275 623963..625351 + 1389 WP_174047149.1 MFS transporter -
At1D132_RS03280 625432..625605 - 174 WP_010971273.1 hypothetical protein -
At1D132_RS03285 625674..627392 - 1719 WP_121650521.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-115)

Antitoxin

SpoVT-AbrB domain

(14-52)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 12856.04 Da        Isoelectric Point: 8.2782

>T112977 WP_121651515.1 NZ_CP033022:623170-623529 [Agrobacterium fabrum]
IVRSQIPKRGDVYLVDLNPVVGSEIKDEHRCVVITPREINAVGLCLVVPVTTGGMFTRKAGLAVNISGHKTTGVALCNQV
RSMDIVARVAQKKAKYIETLDDTTIDEIAGRIISMIDPA

Download         Length: 360 bp

>T112977 NZ_CP033022:623170-623529 [Agrobacterium fabrum]
ATAGTCCGCAGCCAGATCCCCAAGCGCGGCGACGTTTATCTGGTTGATCTAAACCCTGTCGTAGGCAGCGAAATCAAGGA
CGAACATCGCTGTGTCGTCATCACGCCCAGAGAAATTAACGCGGTCGGACTGTGTCTCGTCGTCCCGGTGACCACCGGCG
GCATGTTTACGCGCAAGGCAGGGCTTGCCGTAAATATATCCGGCCACAAGACAACGGGCGTCGCTTTGTGCAATCAGGTG
AGAAGCATGGATATAGTCGCCCGGGTTGCCCAGAAGAAAGCGAAATATATCGAAACCCTCGATGATACGACGATCGATGA
AATCGCCGGGCGCATCATCAGCATGATTGATCCAGCTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9434.99 Da        Isoelectric Point: 5.1106

>AT112977 WP_092770440.1 NZ_CP033022:622904-623170 [Agrobacterium fabrum]
MTVTTRIRRQGGAAVMTIPPALLKMLGLEIGEQLTLEVDNGALVASPVRPEKKRFTLAELLDGAEEVAALNARERAWDTA
PPVGKEAL

Download         Length: 267 bp

>AT112977 NZ_CP033022:622904-623170 [Agrobacterium fabrum]
ATGACCGTGACCACGAGAATAAGACGCCAGGGCGGTGCGGCCGTGATGACCATTCCGCCCGCTCTTTTGAAGATGCTGGG
GCTGGAAATCGGTGAGCAACTGACGCTCGAGGTCGATAATGGCGCTCTGGTGGCAAGCCCGGTTCGACCGGAAAAGAAAC
GCTTCACGCTGGCCGAATTACTGGATGGTGCAGAGGAAGTGGCAGCTCTAAACGCCAGGGAGCGGGCGTGGGACACAGCG
CCTCCTGTCGGCAAAGAAGCGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References