Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2276884..2277410 | Replicon | chromosome |
| Accession | NZ_CP033020 | ||
| Organism | Escherichia coli ATCC 8739 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | D9Q99_RS10900 | Protein ID | WP_000323025.1 |
| Coordinates | 2277123..2277410 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | D9Q99_RS10895 | Protein ID | WP_000534858.1 |
| Coordinates | 2276884..2277123 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D9Q99_RS10865 (2272221) | 2272221..2272710 | + | 490 | Protein_2122 | class I SAM-dependent methyltransferase | - |
| D9Q99_RS10870 (2273188) | 2273188..2273609 | + | 422 | Protein_2123 | hypothetical protein | - |
| D9Q99_RS10875 (2274265) | 2274265..2275287 | + | 1023 | Protein_2124 | ISNCY family transposase | - |
| D9Q99_RS10880 (2275408) | 2275408..2275557 | + | 150 | WP_011443592.1 | protein YdfW | - |
| D9Q99_RS10885 (2276019) | 2276019..2276351 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| D9Q99_RS10890 (2276554) | 2276554..2276859 | - | 306 | WP_001326990.1 | protein YdfV | - |
| D9Q99_RS10895 (2276884) | 2276884..2277123 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| D9Q99_RS10900 (2277123) | 2277123..2277410 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| D9Q99_RS10905 (2277482) | 2277482..2277637 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| D9Q99_RS10910 (2277854) | 2277854..2278105 | + | 252 | WP_000980994.1 | protein Rem | - |
| D9Q99_RS10915 (2278172) | 2278172..2278450 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| D9Q99_RS10920 (2278452) | 2278452..2279501 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| D9Q99_RS10925 (2279515) | 2279515..2280267 | + | 753 | WP_001047134.1 | antitermination protein | - |
| D9Q99_RS10930 (2280545) | 2280545..2280634 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| D9Q99_RS10935 (2280689) | 2280689..2280901 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| D9Q99_RS10940 (2281202) | 2281202..2281417 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| D9Q99_RS10945 (2281781) | 2281781..2281951 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| D9Q99_RS10950 (2282171) | 2282171..2282386 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2258574..2323832 | 65258 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T112966 WP_000323025.1 NZ_CP033020:2277123-2277410 [Escherichia coli ATCC 8739]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T112966 NZ_CP033020:2277123-2277410 [Escherichia coli ATCC 8739]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT112966 WP_000534858.1 NZ_CP033020:2276884-2277123 [Escherichia coli ATCC 8739]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT112966 NZ_CP033020:2276884-2277123 [Escherichia coli ATCC 8739]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|