Detailed information of TA system TA112952

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 6123411..6124474
• Replicon: chromosome
• Accession: NZ_CP033019
• Organism: Janthinobacterium agaricidamnosum strain BHSEK

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: D9M09_RS27645
• Protein ID: WP_121670835.1
• Coordinates: 6123896..6124474 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: D9M09_RS27640
• Protein ID: WP_121670834.1
• Coordinates: 6123411..6123896 (+)
• Length: 162 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D9M09_RS27625	6120071..6122089	+	2019	WP_205602427.1	M13 family peptidase	-
D9M09_RS27630	6122398..6122961	-	564	WP_121670833.1	cytochrome c5 family protein	-
D9M09_RS27640	6123411..6123896	+	486	WP_121670834.1	helix-turn-helix domain-containing protein	Antitoxin
D9M09_RS27645	6123896..6124474	+	579	WP_121670835.1	PIN domain-containing protein	Toxin
D9M09_RS27650	6124769..6127426	+	2658	WP_121670836.1	TonB-dependent receptor	-
D9M09_RS27655	6127540..6128892	+	1353	WP_121670837.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-116)

Antitoxin

• SinI-like, DNA-binding domain (92-136)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21328.59 Da
• Isoelectric Point: 4.8818

>T112952 WP_121670835.1 NZ_CP033019:6123896-6124474 [Janthinobacterium agaricidamnosum]
MAGYYRYTAVLDACVLYPAPLRDLLLSLAADGIFSARWTARIQEEWQRNLLLKRPDLDPSALARTSALMDEAVEDGVIES
YEYLIDALVLPDADDRHVLAAAIVGHADAIVTFNLKDFPDAIMRGHNIEVLHPDDFLVAQYELAPIRMLSVVKENRARLR
KPPRSAAELIATYEAQGLPQLGKLLHSAIALP

Nucleotide

• Length: 579 bp

>T112952 NZ_CP033019:6123896-6124474 [Janthinobacterium agaricidamnosum]
ATGGCTGGATACTACCGTTACACTGCCGTCCTCGATGCCTGTGTGTTGTATCCGGCCCCCTTGCGCGATCTATTGCTGAG
TTTGGCGGCGGACGGTATATTCAGCGCACGCTGGACAGCACGGATACAGGAAGAGTGGCAACGCAATTTGCTACTCAAGC
GGCCTGATCTCGATCCTTCGGCATTGGCGCGCACCAGCGCGCTGATGGACGAGGCGGTCGAAGACGGCGTGATCGAGTCG
TATGAATACCTGATTGATGCCTTGGTCTTGCCCGATGCCGACGACCGGCACGTGCTGGCGGCAGCCATCGTGGGGCATGC
GGACGCCATCGTCACGTTCAATCTTAAAGACTTCCCGGACGCGATCATGCGAGGGCACAACATTGAAGTCTTGCATCCCG
ATGATTTTCTGGTGGCGCAGTATGAACTGGCCCCGATACGCATGCTCAGTGTCGTCAAGGAAAACCGGGCGCGATTGCGC
AAACCGCCCAGATCCGCTGCCGAATTGATTGCCACCTACGAAGCGCAAGGCTTGCCGCAACTGGGGAAGTTGCTGCATTC
CGCAATTGCCTTGCCCTAG

Antitoxin

Protein

• Length: 162 a.a.
• Molecular weight: 18112.70 Da
• Isoelectric Point: 6.3407

>AT112952 WP_121670834.1 NZ_CP033019:6123411-6123896 [Janthinobacterium agaricidamnosum]
MESREDAMSNVLDRLDNKEDLELAKAAQRCLVSALDHSRAVQIAVLEEGAQDLGDAPLLRLPPNVLRLFADVLGTLAQGK
AVTVMPKEHDVTTQEAAMYLNMSRAYLVRLLEAGKIPHHKVGTHRRLRFEDVVQYKDERKRRSQQALQALADQAQELELG
Y

Nucleotide

• Length: 486 bp

>AT112952 NZ_CP033019:6123411-6123896 [Janthinobacterium agaricidamnosum]
ATGGAAAGTAGGGAGGATGCCATGTCGAATGTGCTTGATCGTCTGGACAATAAAGAAGACCTGGAACTGGCGAAGGCGGC
GCAGCGCTGCCTGGTGAGTGCGCTTGATCATTCTCGTGCCGTGCAGATTGCGGTTCTGGAAGAGGGCGCGCAGGACTTGG
GTGATGCACCCTTGCTGCGTTTGCCGCCGAATGTGTTGCGCCTGTTTGCCGATGTCTTAGGTACCTTGGCCCAAGGTAAG
GCCGTGACAGTCATGCCGAAGGAACATGACGTGACGACACAGGAAGCGGCCATGTACCTGAACATGTCACGTGCCTACCT
GGTGCGCCTGCTTGAGGCAGGGAAGATTCCCCATCATAAGGTGGGTACGCACAGGCGGCTGCGCTTTGAGGATGTGGTGC
AGTACAAGGATGAGCGCAAACGGCGTTCGCAACAGGCCTTGCAGGCCTTGGCAGATCAGGCGCAGGAGCTTGAACTGGGG
TACTGA