Detailed information of TA system TA112949

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/StbC(antitoxin)
• Location: 551419..552057
• Replicon: chromosome
• Accession: NZ_CP033019
• Organism: Janthinobacterium agaricidamnosum strain BHSEK

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D9M09_RS02610
• Protein ID: WP_139143048.1
• Coordinates: 551635..552057 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A853SYI4
• Locus tag: D9M09_RS02605
• Protein ID: WP_070219361.1
• Coordinates: 551419..551628 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D9M09_RS28725	547288..548544	-	1257	WP_139143047.1	alpha/beta hydrolase	-
D9M09_RS02590	548762..550000	+	1239	WP_070290173.1	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	-
D9M09_RS02595	549997..550878	+	882	WP_121668507.1	ATP-binding protein	-
D9M09_RS02600	550875..551297	+	423	WP_121668508.1	NUDIX domain-containing protein	-
D9M09_RS02605	551419..551628	+	210	WP_070219361.1	hypothetical protein	Antitoxin
D9M09_RS02610	551635..552057	+	423	WP_139143048.1	type II toxin-antitoxin system VapC family toxin	Toxin
D9M09_RS02615	552061..552252	-	192	WP_034785391.1	DNA gyrase inhibitor YacG	-
D9M09_RS02620	552271..553026	-	756	WP_070219363.1	cell division protein ZapD	-
D9M09_RS02625	553089..553736	-	648	WP_121668509.1	dephospho-CoA kinase	-
D9M09_RS02630	553759..554628	-	870	WP_162995548.1	A24 family peptidase	-
D9M09_RS02635	554914..555504	-	591	WP_070290185.1	DUF2867 domain-containing protein	-
D9M09_RS02640	555691..556080	-	390	WP_121668510.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-116)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15090.46 Da
• Isoelectric Point: 5.6428

>T112949 WP_139143048.1 NZ_CP033019:551635-552057 [Janthinobacterium agaricidamnosum]
MPMPAYLVDTDVIVAARKGSAAPAGVADFFERVAPELRYVPVQVIAQLRAGIQCSWRREAALEALALEGWLEAVLAEYAP
RLLEFDLDCALVCARLHGRSHAHGVDGQIAAMGIAYGLTVVSGRLDSFAAQGLRLENPFK

Nucleotide

• Length: 423 bp

>T112949 NZ_CP033019:551635-552057 [Janthinobacterium agaricidamnosum]
ATGCCTATGCCCGCCTATCTGGTCGATACGGATGTGATCGTTGCTGCGCGCAAGGGCAGTGCTGCGCCGGCGGGCGTGGC
CGATTTTTTCGAGCGGGTAGCGCCGGAGTTGCGTTATGTGCCGGTGCAGGTGATCGCGCAATTGCGCGCAGGCATACAGT
GCAGCTGGCGGCGCGAAGCGGCGCTGGAAGCACTGGCGCTGGAGGGCTGGCTGGAAGCCGTGCTGGCGGAATATGCGCCG
CGGCTGCTGGAATTCGACCTCGATTGCGCGCTCGTGTGCGCGCGTCTGCATGGCCGTAGTCACGCGCATGGCGTCGATGG
GCAGATCGCGGCGATGGGCATTGCCTATGGCTTGACGGTGGTCAGCGGCAGGCTCGACAGTTTCGCGGCGCAGGGGCTGC
GCCTGGAAAATCCATTCAAATGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7912.09 Da
• Isoelectric Point: 6.7248

>AT112949 WP_070219361.1 NZ_CP033019:551419-551628 [Janthinobacterium agaricidamnosum]
MPLTLTFTDTDELLIAALHKRARAHGRSIEDEHRDILRSALRPLPKRPLDDILRGMPDVGLDADFERRP

Nucleotide

• Length: 210 bp

>AT112949 NZ_CP033019:551419-551628 [Janthinobacterium agaricidamnosum]
ATGCCGCTGACACTGACCTTTACCGATACCGATGAATTGCTGATTGCCGCCTTGCACAAGCGTGCCCGCGCGCATGGGCG
CAGCATCGAAGACGAGCACCGCGACATCCTGCGCAGCGCCTTGCGGCCCTTGCCGAAGCGCCCGCTCGACGATATTTTGC
GCGGCATGCCCGACGTGGGCCTGGACGCGGATTTCGAGCGCCGCCCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A853SYI4