Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1763662..1764493 Replicon chromosome
Accession NZ_CP032992
Organism Escherichia coli strain W5-6

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag D9V54_RS08555 Protein ID WP_000854814.1
Coordinates 1763662..1764036 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag D9V54_RS08560 Protein ID WP_001285585.1
Coordinates 1764125..1764493 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9V54_RS08515 1759058..1760224 + 1167 WP_000830163.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
D9V54_RS08520 1760343..1760816 + 474 WP_001105393.1 DNA gyrase inhibitor SbmC -
D9V54_RS08525 1761014..1762072 + 1059 WP_001200905.1 FUSC family protein -
D9V54_RS08530 1762244..1762573 + 330 WP_000450409.1 DUF496 family protein -
D9V54_RS08535 1762674..1762856 - 183 WP_001016348.1 hypothetical protein -
D9V54_RS08540 1762910..1763056 + 147 Protein_1633 transposase domain-containing protein -
D9V54_RS08545 1763345..1763458 - 114 WP_001161660.1 DUF957 domain-containing protein -
D9V54_RS08550 1763471..1763665 - 195 WP_000988600.1 hypothetical protein -
D9V54_RS08555 1763662..1764036 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
D9V54_RS08560 1764125..1764493 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
D9V54_RS08565 1764567..1764788 - 222 WP_000692323.1 DUF987 domain-containing protein -
D9V54_RS08570 1764851..1765327 - 477 WP_001186773.1 RadC family protein -
D9V54_RS08575 1765343..1765822 - 480 WP_000860076.1 antirestriction protein -
D9V54_RS08580 1765904..1766725 - 822 WP_001234530.1 DUF945 domain-containing protein -
D9V54_RS08590 1766946..1767356 - 411 WP_000846713.1 hypothetical protein -
D9V54_RS08595 1767372..1767779 - 408 Protein_1643 hypothetical protein -
D9V54_RS08600 1767794..1768491 - 698 Protein_1644 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1767794..1768087 293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T112929 WP_000854814.1 NZ_CP032992:c1764036-1763662 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T112929 NZ_CP032992:c1764036-1763662 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT112929 WP_001285585.1 NZ_CP032992:c1764493-1764125 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT112929 NZ_CP032992:c1764493-1764125 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References