Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4218990..4219825 Replicon chromosome
Accession NZ_CP032989
Organism Escherichia coli strain W2-5

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2S4A272
Locus tag D9V55_RS20890 Protein ID WP_001094443.1
Coordinates 4218990..4219367 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag D9V55_RS20895 Protein ID WP_001285607.1
Coordinates 4219457..4219825 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9V55_RS20855 4214350..4215330 + 981 WP_001366032.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
D9V55_RS20860 4215338..4215460 - 123 WP_001338066.1 hypothetical protein -
D9V55_RS20865 4215542..4216414 + 873 WP_000168567.1 HNH endonuclease -
D9V55_RS20870 4216525..4217523 - 999 WP_001240355.1 membrane protein -
D9V55_RS25495 4218062..4218208 - 147 WP_001290178.1 hypothetical protein -
D9V55_RS20880 4218293..4218490 - 198 WP_121636723.1 DUF957 domain-containing protein -
D9V55_RS20885 4218502..4218993 - 492 WP_023155722.1 hypothetical protein -
D9V55_RS20890 4218990..4219367 - 378 WP_001094443.1 TA system toxin CbtA family protein Toxin
D9V55_RS20895 4219457..4219825 - 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
D9V55_RS20900 4219905..4220126 - 222 WP_000692350.1 DUF987 domain-containing protein -
D9V55_RS20905 4220213..4220689 - 477 WP_001384029.1 RadC family protein -
D9V55_RS20910 4220704..4221189 - 486 WP_000213722.1 antirestriction protein -
D9V55_RS20915 4221281..4222099 - 819 WP_001175175.1 DUF945 domain-containing protein -
D9V55_RS20920 4222189..4222398 - 210 WP_032150870.1 DUF905 family protein -
D9V55_RS20925 4222428..4223105 - 678 WP_001097301.1 hypothetical protein -
D9V55_RS20930 4223253..4223933 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4210386..4238514 28128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14058.97 Da        Isoelectric Point: 7.3523

>T112907 WP_001094443.1 NZ_CP032989:c4219367-4218990 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T112907 NZ_CP032989:c4219367-4218990 [Escherichia coli]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT112907 WP_001285607.1 NZ_CP032989:c4219825-4219457 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT112907 NZ_CP032989:c4219825-4219457 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4A272

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References