Detailed information of TA system TA112889

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 817533..818368
• Replicon: chromosome
• Accession: NZ_CP032989
• Organism: Escherichia coli strain W2-5

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: D9V55_RS04140
• Protein ID: WP_063090830.1
• Coordinates: 817533..817910 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: D9V55_RS04145
• Protein ID: WP_024174331.1
• Coordinates: 818000..818368 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D9V55_RS04110	812941..813918	+	978	WP_000633235.1	type II secretion system minor pseudopilin GspK	-
D9V55_RS04115	813915..815093	+	1179	WP_000094957.1	type II secretion system protein GspL	-
D9V55_RS04120	815095..815631	+	537	WP_000942795.1	GspM family type II secretion system protein YghD	-
D9V55_RS04125	815912..816754	-	843	WP_042096658.1	DUF4942 domain-containing protein	-
D9V55_RS04130	816839..817036	-	198	WP_000838536.1	DUF957 domain-containing protein	-
D9V55_RS04135	817048..817536	-	489	WP_042096656.1	hypothetical protein	-
D9V55_RS04140	817533..817910	-	378	WP_063090830.1	TA system toxin CbtA family protein	Toxin
D9V55_RS04145	818000..818368	-	369	WP_024174331.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
D9V55_RS04150	818442..818663	-	222	WP_000692346.1	DUF987 domain-containing protein	-
D9V55_RS04155	818732..819208	-	477	WP_001186725.1	RadC family protein	-
D9V55_RS04160	819224..819709	-	486	WP_042096390.1	antirestriction protein	-
D9V55_RS04165	819801..820619	-	819	WP_001234749.1	DUF945 domain-containing protein	-
D9V55_RS04170	820710..820943	-	234	WP_001117568.1	DUF905 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14210.15 Da
• Isoelectric Point: 6.8518

>T112889 WP_063090830.1 NZ_CP032989:c817910-817533 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLGF
SACTRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ

Nucleotide

• Length: 378 bp

>T112889 NZ_CP032989:c817910-817533 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCTGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13603.42 Da
• Isoelectric Point: 6.7386

>AT112889 WP_024174331.1 NZ_CP032989:c818368-818000 [Escherichia coli]
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKT

Nucleotide

• Length: 369 bp

>AT112889 NZ_CP032989:c818368-818000 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAACGTAA