Detailed information of TA system
Overview
TA module
| Type | V | Classification (family/domain) | ghoTS/ghoT-GhoS |
| Location | 4199607..4200104 | Replicon | chromosome |
| Accession | NZ_CP032986 | ||
| Organism | Escherichia coli strain BE2-5 | ||
Toxin (Protein)
| Gene name | ghoT | Uniprot ID | - |
| Locus tag | D9V56_RS20640 | Protein ID | WP_077492245.1 |
| Coordinates | 4199607..4199780 (-) | Length | 58 a.a. |
Antitoxin (Protein)
| Gene name | ghoS | Uniprot ID | L4JK92 |
| Locus tag | D9V56_RS20645 | Protein ID | WP_000398619.1 |
| Coordinates | 4199808..4200104 (-) | Length | 99 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D9V56_RS20630 | 4196277..4197734 | + | 1458 | WP_000856841.1 | dipeptide/tripeptide permease DtpC | - |
| D9V56_RS20635 | 4197971..4199488 | + | 1518 | WP_001295074.1 | lysine--tRNA ligase | - |
| D9V56_RS20640 | 4199607..4199780 | - | 174 | WP_077492245.1 | type V toxin-antitoxin system toxin GhoT | Toxin |
| D9V56_RS20645 | 4199808..4200104 | - | 297 | WP_000398619.1 | type V toxin-antitoxin system endoribonuclease antitoxin GhoS | Antitoxin |
| D9V56_RS20650 | 4200331..4200603 | - | 273 | WP_000405651.1 | N-acetyltransferase | - |
| D9V56_RS20655 | 4200615..4200845 | - | 231 | WP_000371704.1 | (4Fe-4S)-binding protein | - |
| D9V56_RS20660 | 4201026..4202657 | + | 1632 | WP_121689853.1 | sensor histidine kinase | - |
| D9V56_RS20665 | 4202654..4203373 | + | 720 | WP_000611288.1 | two-component system response regulator DcuR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 58 a.a. Molecular weight: 6631.16 Da Isoelectric Point: 9.9031
>T112884 WP_077492245.1 NZ_CP032986:c4199780-4199607 [Escherichia coli]
MALFYKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
MALFYKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
Download Length: 174 bp
>T112884 NZ_CP032986:c4199780-4199607 [Escherichia coli]
ATGGCACTATTCTATAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTATAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 99 a.a. Molecular weight: 11467.97 Da Isoelectric Point: 4.1705
>AT112884 WP_000398619.1 NZ_CP032986:c4200104-4199808 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK
Download Length: 297 bp
>AT112884 NZ_CP032986:c4200104-4199808 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGACTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGACTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|