Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 372038..372669 Replicon plasmid pAt1D1460
Accession NZ_CP032928
Organism Agrobacterium tumefaciens strain 1D1460

Toxin (Protein)


Gene name vapC Uniprot ID A0A822VAP2
Locus tag At1D1460_RS26335 Protein ID WP_060725879.1
Coordinates 372038..372439 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A822VB92
Locus tag At1D1460_RS26340 Protein ID WP_060725878.1
Coordinates 372439..372669 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
At1D1460_RS26310 367542..368330 - 789 WP_121593584.1 SDR family oxidoreductase -
At1D1460_RS26315 368440..369000 + 561 WP_162993134.1 TetR/AcrR family transcriptional regulator -
At1D1460_RS26320 369909..370739 + 831 WP_121593586.1 AraC family transcriptional regulator -
At1D1460_RS26325 370851..371495 + 645 WP_060725880.1 LysE family translocator -
At1D1460_RS26330 371732..371962 + 231 WP_060726006.1 BrnA antitoxin family protein -
At1D1460_RS26335 372038..372439 - 402 WP_060725879.1 tRNA(fMet)-specific endonuclease VapC Toxin
At1D1460_RS26340 372439..372669 - 231 WP_060725878.1 antitoxin Antitoxin
At1D1460_RS26345 372881..374512 - 1632 WP_121593587.1 GMC family oxidoreductase -
At1D1460_RS26350 374705..375499 - 795 WP_121593588.1 alpha/beta hydrolase -
At1D1460_RS26355 375644..376111 + 468 WP_121593589.1 MarR family transcriptional regulator -
At1D1460_RS26360 376138..376917 - 780 WP_121593590.1 SDR family oxidoreductase -
At1D1460_RS26365 376914..377243 - 330 WP_121593591.1 nuclear transport factor 2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..520191 520191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 19739.68 Da        Isoelectric Point: 5.5500

>T112862 WP_060725879.1 NZ_CP032928:c372439-372038 [Agrobacterium tumefaciens]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 402 bp

>T112862 NZ_CP032928:c372439-372038 [Agrobacterium tumefaciens]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 11350.61 Da        Isoelectric Point: 5.5500

>AT112862 WP_060725878.1 NZ_CP032928:c372669-372439 [Agrobacterium tumefaciens]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 231 bp

>AT112862 NZ_CP032928:c372669-372439 [Agrobacterium tumefaciens]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822VAP2

Antitoxin

Source ID Structure
AlphaFold DB A0A822VB92

References