Detailed information of TA system TA112858

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 150680..151260
• Replicon: plasmid pAt1D1108a
• Accession: NZ_CP032923
• Organism: Agrobacterium tumefaciens strain 1D1108

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: At1D1108_RS24330
• Protein ID: WP_080802578.1
• Coordinates: 150680..151063 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: F0LFX8
• Locus tag: At1D1108_RS24335
• Protein ID: WP_013637280.1
• Coordinates: 151060..151260 (-)
• Length: 67 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
At1D1108_RS24305	146022..146810	+	789	WP_019565642.1	ATP-binding cassette domain-containing protein	-
At1D1108_RS24310	146895..147689	+	795	WP_121557676.1	TIM barrel protein	-
At1D1108_RS24315	147713..148732	+	1020	WP_121557677.1	Gfo/Idh/MocA family oxidoreductase	-
At1D1108_RS24325	149371..150267	-	897	WP_080802577.1	transglutaminase family protein	-
At1D1108_RS24330	150680..151063	-	384	WP_080802578.1	type II toxin-antitoxin system VapC family toxin	Toxin
At1D1108_RS24335	151060..151260	-	201	WP_013637280.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
At1D1108_RS24340	151486..152427	-	942	WP_080802580.1	AraC family transcriptional regulator	-
At1D1108_RS24345	152519..153496	+	978	WP_080802583.1	SDR family NAD(P)-dependent oxidoreductase	-
At1D1108_RS24350	153762..154208	-	447	WP_080802585.1	carboxymuconolactone decarboxylase family protein	-
At1D1108_RS24355	154301..154738	-	438	WP_003517453.1	cupin domain-containing protein	-
At1D1108_RS24360	154752..155504	-	753	WP_019565667.1	NAD(P)H-binding protein	-
At1D1108_RS24365	155516..156028	-	513	WP_019565668.1	Rrf2 family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..502274	502274

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-133)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 18856.62 Da
• Isoelectric Point: 5.5500

>T112858 WP_080802578.1 NZ_CP032923:c151063-150680 [Agrobacterium tumefaciens]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 384 bp

>T112858 NZ_CP032923:c151063-150680 [Agrobacterium tumefaciens]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 67 a.a.
• Molecular weight: 9878.85 Da
• Isoelectric Point: 5.5500

>AT112858 WP_013637280.1 NZ_CP032923:c151260-151060 [Agrobacterium tumefaciens]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 201 bp

>AT112858 NZ_CP032923:c151260-151060 [Agrobacterium tumefaciens]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Antitoxin

• AlphaFold DB: F0LFX8