Detailed information of TA system TA112841

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1129486..1130002
• Replicon: chromosome
• Accession: NZ_CP032916
• Organism: Enterobacter roggenkampii strain ECY546

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0W2HDR3
• Locus tag: D8675_RS06575
• Protein ID: WP_008501399.1
• Coordinates: 1129486..1129770 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D8675_RS06580
• Protein ID: WP_129694030.1
• Coordinates: 1129760..1130002 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D8675_RS06560	1125832..1126404	+	573	WP_023326578.1	fructose PTS transporter subunit IIA	-
D8675_RS06565	1126774..1128912	+	2139	WP_129694029.1	anaerobic ribonucleoside-triphosphate reductase	-
D8675_RS06570	1129018..1129482	+	465	WP_023326577.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
D8675_RS06575	1129486..1129770	-	285	WP_008501399.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D8675_RS06580	1129760..1130002	-	243	WP_129694030.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
D8675_RS06585	1130080..1131990	-	1911	WP_045371705.1	BglG family transcription antiterminator	-
D8675_RS06590	1132010..1133146	-	1137	WP_045371707.1	lactonase family protein	-
D8675_RS06595	1133172..1133912	-	741	WP_021240686.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10768.53 Da
• Isoelectric Point: 10.3039

>T112841 WP_008501399.1 NZ_CP032916:c1129770-1129486 [Enterobacter roggenkampii]
MTYELEFDPRALKEWSKLGDTVKNQFKKKLAGVLANPRVESARLHNLPDCYKIKLKASGYRLVYQVQDSVITVFVIAVGK
REKSAAYHDANKRL

Nucleotide

• Length: 285 bp

>T112841 NZ_CP032916:c1129770-1129486 [Enterobacter roggenkampii]
ATGACTTATGAACTGGAATTTGACCCGAGGGCGTTAAAGGAGTGGAGCAAGCTGGGGGATACGGTCAAAAACCAGTTTAA
GAAGAAACTTGCCGGGGTATTGGCAAATCCCCGGGTCGAATCGGCCCGCCTGCATAATCTGCCTGATTGCTACAAAATCA
AACTCAAGGCGTCTGGCTATCGCCTGGTTTATCAGGTTCAGGACAGCGTTATAACGGTATTTGTTATCGCCGTTGGGAAA
AGAGAGAAATCAGCCGCTTATCACGACGCAAATAAACGGCTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8986.44 Da
• Isoelectric Point: 6.3127

>AT112841 WP_129694030.1 NZ_CP032916:c1130002-1129760 [Enterobacter roggenkampii]
MATLNVRLDDKLKKEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT112841 NZ_CP032916:c1130002-1129760 [Enterobacter roggenkampii]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCAATATTACCCC
AACGGAAGCGGTGCGATTGCTGTTTCAGTACGTTGCTGAAACGGGGCGCATGCCGGTGAAAACGGTCACCATTAGCGACA
GCGAAGATGCGCTGATACAGACAGTCCGGGAGCGACTGGCTAATCCGCAAAAGGGAATAAAGGTTAGTCTGGATGACTTA
TGA

Structures

Toxin

• AlphaFold DB: A0A0W2HDR3