Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1199752..1200367 Replicon chromosome
Accession NZ_CP032912
Organism Helicobacter pylori strain 13-A-EK8

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D4H18_RS05945 Protein ID WP_139523072.1
Coordinates 1200050..1200367 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D4H18_RS05940 Protein ID WP_139523071.1
Coordinates 1199752..1200063 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D4H18_RS05910 1195497..1196255 + 759 WP_139523069.1 HugZ family heme oxygenase -
D4H18_RS05920 1196540..1198731 + 2192 Protein_1103 outer membrane beta-barrel protein -
D4H18_RS05930 1199166..1199426 + 261 WP_139523070.1 hypothetical protein -
D4H18_RS05935 1199407..1199673 + 267 Protein_1105 type II toxin-antitoxin system YafQ family toxin -
D4H18_RS05940 1199752..1200063 + 312 WP_139523071.1 hypothetical protein Antitoxin
D4H18_RS05945 1200050..1200367 + 318 WP_139523072.1 type II toxin-antitoxin system YafQ family toxin Toxin
D4H18_RS05950 1200724..1201869 + 1146 WP_139523073.1 YbfB/YjiJ family MFS transporter -
D4H18_RS05955 1201875..1202837 - 963 WP_139523074.1 GTP-binding protein -
D4H18_RS05960 1202837..1203211 - 375 WP_033589937.1 hypothetical protein -
D4H18_RS05965 1203258..1204139 - 882 WP_078248806.1 polysaccharide deacetylase -
D4H18_RS05970 1204152..1205036 - 885 WP_139523075.1 carbon-nitrogen hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12099.49 Da        Isoelectric Point: 10.2207

>T112837 WP_139523072.1 NZ_CP032912:1200050-1200367 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLATEQPLAPKYKDHPLKGGLKDFRECHLKPDLLLVYQIKKPKNTLFL
VRLGSHSELFYKSPITPKKNATIAC

Download         Length: 318 bp

>T112837 NZ_CP032912:1200050-1200367 [Helicobacter pylori]
ATGCTGATGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCACAGAGCAACCCCTAGCTCCCAAATACAAAGACCACCCGCTCAAAGGCGGTTTAA
AAGATTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACCAAAAAACACCCTCTTTTTA
GTAAGGTTAGGCAGTCATAGCGAGTTGTTTTATAAATCACCCATAACGCCTAAAAAGAACGCAACAATCGCATGCTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12231.08 Da        Isoelectric Point: 10.1455

>AT112837 WP_139523071.1 NZ_CP032912:1199752-1200063 [Helicobacter pylori]
MPNTTAKKDYTKYSEKQLVNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKDH
LCFKSVEDFKKHCENLRFKNADD

Download         Length: 312 bp

>AT112837 NZ_CP032912:1199752-1200063 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTGTTAATTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAGGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CACTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGATACTAAGGACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAAAAACATTGTGAAAACTTAAGATTTAAAAATGCTGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References