Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 869188..869812 Replicon chromosome
Accession NZ_CP032911
Organism Helicobacter pylori strain 19-A-EK3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D4H43_RS04160 Protein ID WP_139544107.1
Coordinates 869188..869454 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D4H43_RS04165 Protein ID WP_139544108.1
Coordinates 869441..869812 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D4H43_RS04135 865819..866586 - 768 WP_000242353.1 ABC transporter ATP-binding protein -
D4H43_RS04140 866586..867566 - 981 WP_000921461.1 iron ABC transporter permease -
D4H43_RS04145 867559..868413 - 855 WP_139544106.1 SDR family oxidoreductase -
D4H43_RS04150 868553..869077 + 525 WP_001135623.1 acyl-CoA thioesterase -
D4H43_RS04160 869188..869454 - 267 WP_139544107.1 type II toxin-antitoxin system YafQ family toxin Toxin
D4H43_RS04165 869441..869812 - 372 WP_139544108.1 hypothetical protein Antitoxin
D4H43_RS04170 870022..872253 - 2232 WP_139548809.1 outer membrane beta-barrel protein -
D4H43_RS04185 872606..873240 + 635 Protein_789 hypothetical protein -
D4H43_RS04190 873191..874303 - 1113 WP_139548810.1 hydrogenase formation protein HypD -
D4H43_RS04195 874321..874557 - 237 WP_139544111.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10537.50 Da        Isoelectric Point: 10.0710

>T112835 WP_139544107.1 NZ_CP032911:c869454-869188 [Helicobacter pylori]
MLKIKHHILYKKDFKKLVKNGFDDSVLNEVILTLRKKEPLDPRFQDHALKGKWKPFRECHIKSDILLVYLVRDDELVLLR
LGSHNELF

Download         Length: 267 bp

>T112835 NZ_CP032911:c869454-869188 [Helicobacter pylori]
ATGCTGAAAATTAAGCACCATATCCTTTACAAAAAAGATTTTAAAAAGCTTGTTAAAAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAGAAAGAACCGCTAGATCCACGATTTCAAGATCATGCCTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCATATTAAATCCGACATTTTGCTTGTGTATTTAGTGCGAGATGATGAGCTTGTTTTGTTAAGG
TTAGGCAGTCATAACGAGCTGTTTTAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 14580.45 Da        Isoelectric Point: 6.4798

>AT112835 WP_139544108.1 NZ_CP032911:c869812-869441 [Helicobacter pylori]
MPNTTAKKDYTKYSERQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GHETPNIQTQQAMRDALKDENLETIEDFSAWANEVKKEVNAEN

Download         Length: 372 bp

>AT112835 NZ_CP032911:c869812-869441 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAGACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCGTTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCATGAAACCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCATTAAAAGATGAAAACTTAGAAACTATTGAAGA
CTTTTCTGCATGGGCAAATGAAGTGAAAAAGGAAGTGAATGCTGAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References