Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1193691..1194348 Replicon chromosome
Accession NZ_CP032910
Organism Helicobacter pylori strain 20-A-EK1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D4H71_RS05885 Protein ID WP_139548424.1
Coordinates 1194037..1194348 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D4H71_RS05880 Protein ID WP_139548423.1
Coordinates 1193691..1194056 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D4H71_RS05870 1189448..1190203 + 756 WP_139548422.1 HugZ family heme oxygenase -
D4H71_RS05875 1190505..1192738 + 2234 Protein_1096 Hop family adhesin BabA -
D4H71_RS05880 1193691..1194056 + 366 WP_139548423.1 hypothetical protein Antitoxin
D4H71_RS05885 1194037..1194348 + 312 WP_139548424.1 type II toxin-antitoxin system YafQ family toxin Toxin
D4H71_RS05895 1194710..1195855 + 1146 WP_139548426.1 YbfB/YjiJ family MFS transporter -
D4H71_RS05900 1195861..1196826 - 966 WP_139548427.1 GTP-binding protein -
D4H71_RS05905 1196826..1197200 - 375 WP_033589937.1 hypothetical protein -
D4H71_RS05910 1197247..1198128 - 882 WP_001040362.1 polysaccharide deacetylase -
D4H71_RS05915 1198159..1199037 - 879 WP_139548428.1 carbon-nitrogen hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11887.16 Da        Isoelectric Point: 9.9223

>T112833 WP_139548424.1 NZ_CP032910:1194037-1194348 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLKEVILTLRKKEPLPPPFKDHALKGVWKPYRECHIKADVLLVYLVKDDELILLR
LGSHSELFYKSPITPKKNATIAC

Download         Length: 312 bp

>T112833 NZ_CP032910:1194037-1194348 [Helicobacter pylori]
GTGTTGAAGCTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAAAGAAGTCATTCTGACCTTGAGAAAGAAAGAACCGCTACCCCCACCATTTAAAGATCACGCTTTAAAGGGGGTTTGGA
AGCCTTATAGAGAATGCCATATCAAAGCTGATGTTTTGCTTGTGTATTTAGTGAAAGATGATGAACTGATTTTGTTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTATAAATCACCCATAACGCCTAAAAAGAACGCAACAATCGCATGCTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 14328.22 Da        Isoelectric Point: 7.8110

>AT112833 WP_139548423.1 NZ_CP032910:1193691-1194056 [Helicobacter pylori]
MPNATNKDYTKYSQRQLFNLMNKKEQEIEKLKRDRVYLEKKMAKELEKKDKGFTIKLEELNKILQEINKRANDCCFGHET
PNIETQQAMREADNKETDLFVEDFSSYSNERKKALGVEAQS

Download         Length: 366 bp

>AT112833 NZ_CP032910:1193691-1194056 [Helicobacter pylori]
ATGCCAAACGCCACCAACAAAGATTACACAAAATACAGCCAAAGACAGCTTTTTAACCTCATGAATAAGAAAGAACAAGA
AATTGAAAAGCTAAAAAGAGATAGGGTATATCTTGAAAAGAAAATGGCTAAAGAGCTAGAGAAAAAAGATAAAGGTTTCA
CTATCAAATTAGAAGAATTGAACAAAATCTTACAAGAAATCAACAAAAGAGCTAATGATTGTTGTTTTGGGCATGAAACC
CCAAACATTGAAACGCAACAAGCCATGAGAGAAGCGGATAACAAAGAAACAGATTTGTTCGTTGAGGATTTTTCTAGTTA
TAGCAATGAAAGAAAAAAGGCTTTAGGTGTTGAAGCTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References