Detailed information of TA system TA112830

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 547211..547781
• Replicon: chromosome
• Accession: NZ_CP032909
• Organism: Helicobacter pylori strain 21-A-EK1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D4I01_RS02790
• Protein ID: WP_139542898.1
• Coordinates: 547509..547781 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D4I01_RS02785
• Protein ID: WP_139542897.1
• Coordinates: 547211..547522 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D4I01_RS02755	543181..543828	-	648	Protein_512	hypothetical protein	-
D4I01_RS02775	544218..546431	+	2214	WP_139545816.1	outer membrane beta-barrel protein	-
D4I01_RS02785	547211..547522	+	312	WP_139542897.1	hypothetical protein	Antitoxin
D4I01_RS02790	547509..547781	+	273	WP_139542898.1	type II toxin-antitoxin system mRNA interferase toxin, HP0892 family	Toxin
D4I01_RS02795	547890..548414	-	525	WP_033592703.1	acyl-CoA thioesterase	-
D4I01_RS02800	548554..549402	+	849	WP_139542899.1	SDR family oxidoreductase	-
D4I01_RS02805	549395..550375	+	981	WP_000921449.1	iron ABC transporter permease	-
D4I01_RS02810	550375..551142	+	768	WP_139542900.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10511.49 Da
• Isoelectric Point: 9.9378

>T112830 WP_139542898.1 NZ_CP032909:547509-547781 [Helicobacter pylori]
MLTIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLAPKYKDHPLKGGLKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T112830 NZ_CP032909:547509-547781 [Helicobacter pylori]
ATGCTGACGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAACTTTT
GTATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGCTCCCAAATACAAAGATCACCCACTCAAAGGCGGTTTAA
AAGATTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATCAAAAAACAAGAAAACACCCTCTTTTTA
GTAAGACTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12305.17 Da
• Isoelectric Point: 10.3856

>AT112830 WP_139542897.1 NZ_CP032909:547211-547522 [Helicobacter pylori]
MPNTTAKKDYTKYSQRQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADD

Nucleotide

• Length: 312 bp

>AT112830 NZ_CP032909:547211-547522 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCCAAAGACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAGGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CACTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGATACCAAGAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAGAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGACGATTGA