Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1147113..1147683 Replicon chromosome
Accession NZ_CP032908
Organism Helicobacter pylori strain 23-A-EK1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D4I31_RS05515 Protein ID WP_139534959.1
Coordinates 1147113..1147385 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D4I31_RS05520 Protein ID WP_139534960.1
Coordinates 1147372..1147683 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D4I31_RS05495 1143750..1144517 - 768 WP_000242352.1 ABC transporter ATP-binding protein -
D4I31_RS05500 1144517..1145497 - 981 WP_000921454.1 iron ABC transporter permease -
D4I31_RS05505 1145490..1146344 - 855 WP_139534958.1 SDR family oxidoreductase -
D4I31_RS05510 1146484..1147008 + 525 WP_001135623.1 acyl-CoA thioesterase -
D4I31_RS05515 1147113..1147385 - 273 WP_139534959.1 type II toxin-antitoxin system mRNA interferase toxin, HP0892 family Toxin
D4I31_RS05520 1147372..1147683 - 312 WP_139534960.1 hypothetical protein Antitoxin
D4I31_RS05530 1147764..1148024 - 261 WP_139534961.1 type II toxin-antitoxin system YafQ family toxin -
D4I31_RS05535 1148011..1148212 - 202 Protein_1055 hypothetical protein -
D4I31_RS08230 1148209..1148379 - 171 WP_161593993.1 hypothetical protein -
D4I31_RS05540 1148761..1150965 - 2205 WP_139534235.1 Hop family adhesin BabA -
D4I31_RS05560 1151533..1152167 + 635 Protein_1058 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10485.49 Da        Isoelectric Point: 10.0798

>T112828 WP_139534959.1 NZ_CP032908:c1147385-1147113 [Helicobacter pylori]
MLTIETSKKFDKDLKILVKNGFDLKLLYKVVGNLATEQPLEPKYKDHPLKGTLKDFRECHLKPDLLLVYQIKKQENTLFL
VKLGSHSKLF

Download         Length: 273 bp

>T112828 NZ_CP032908:c1147385-1147113 [Helicobacter pylori]
ATGCTGACGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
GTATAAAGTGGTTGGAAATTTAGCCACAGAGCAACCCCTAGAACCCAAATACAAAGACCACCCACTCAAAGGCACTTTAA
AAGATTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATCAAAAAACAAGAAAACACCCTCTTTTTA
GTAAAACTAGGCAGTCATAGCAAGCTGTTTTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12332.10 Da        Isoelectric Point: 9.9012

>AT112828 WP_139534960.1 NZ_CP032908:c1147683-1147372 [Helicobacter pylori]
MPNTTAEKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALNLTENGYTIEEEREILVRAKDTKNH
FCFKSIEDFKKHCENLRFKNADD

Download         Length: 312 bp

>AT112828 NZ_CP032908:c1147683-1147372 [Helicobacter pylori]
ATGCCTAACACCACCGCAGAAAAAGACTACACCCAATACAGCGAAAAACAGCTTTTTAATTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CGCTAAACCTAACCGAAAATGGATACACCATAGAAGAAGAGCGAGAAATCTTAGTAAGGGCTAAAGATACCAAGAACCAC
TTTTGTTTTAAAAGCATAGAGGATTTTAAAAAACATTGTGAAAACTTAAGATTTAAAAATGCTGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References