Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1137108..1137729 Replicon chromosome
Accession NZ_CP032907
Organism Helicobacter pylori strain 24-A-EK1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D4I62_RS05440 Protein ID WP_078260894.1
Coordinates 1137108..1137374 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D4I62_RS05445 Protein ID WP_139533594.1
Coordinates 1137355..1137729 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D4I62_RS05410 1133085..1133852 - 768 WP_000242349.1 ABC transporter ATP-binding protein -
D4I62_RS05415 1133852..1134832 - 981 WP_000921461.1 iron ABC transporter permease -
D4I62_RS05420 1134825..1135679 - 855 WP_139533592.1 SDR family oxidoreductase -
D4I62_RS05425 1135819..1136343 + 525 WP_001135623.1 acyl-CoA thioesterase -
D4I62_RS05430 1136450..1136723 - 274 Protein_1033 type II toxin-antitoxin system YafQ family toxin -
D4I62_RS05435 1136737..1137027 - 291 WP_139533593.1 type II toxin-antitoxin system antitoxin -
D4I62_RS05440 1137108..1137374 - 267 WP_078260894.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
D4I62_RS05445 1137355..1137729 - 375 WP_139533594.1 hypothetical protein Antitoxin
D4I62_RS05455 1138171..1140411 - 2241 WP_139533596.1 Hop family adhesin BabA -
D4I62_RS05470 1140837..1141471 + 635 Protein_1038 hypothetical protein -
D4I62_RS05475 1141422..1142534 - 1113 WP_139533597.1 hydrogenase formation protein HypD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10332.17 Da        Isoelectric Point: 8.0602

>T112826 WP_078260894.1 NZ_CP032907:c1137374-1137108 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVKDDELILLR
LGSHSELF

Download         Length: 267 bp

>T112826 NZ_CP032907:c1137374-1137108 [Helicobacter pylori]
GTGTTGAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTGACCTTGAGAAAAAAAGAACCGCTAGATCCACAATTTCAAGATCATGCCCTAAAAGGCAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCCGACATTTTGCTTGTGTATTTAGTGAAAGATGATGAACTGATTTTGTTAAGG
TTAGGCAGTCATAGCGAGTTGTTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14690.66 Da        Isoelectric Point: 9.0211

>AT112826 WP_139533594.1 NZ_CP032907:c1137729-1137355 [Helicobacter pylori]
MPNTTNKDYTQYSEKQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCLG
RKIPNIQTQQAMRDALNKETDLIVEDFSSYSNERKRALGVETQS

Download         Length: 375 bp

>AT112826 NZ_CP032907:c1137729-1137355 [Helicobacter pylori]
ATGCCAAACACCACCAACAAAGATTACACCCAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCGAAA
AATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGAGATCAAAACTTTA
AGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTGTTTGGGG
CGCAAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCACTCAACAAAGAGACAGATTTGATTGTTGAGGATTT
TTCTAGTTACAGCAATGAAAGAAAAAGGGCTTTAGGTGTTGAAACTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References