Detailed information of TA system TA112822

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 1258081..1258537
• Replicon: chromosome
• Accession: NZ_CP032905
• Organism: Helicobacter pylori strain 26-A-EK1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D4J22_RS06260
• Protein ID: WP_139547092.1
• Coordinates: 1258376..1258537 (+)
• Length: 54 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D4J22_RS06255
• Protein ID: WP_139547091.1
• Coordinates: 1258081..1258389 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D4J22_RS06240	1254167..1254922	+	756	WP_120847193.1	HugZ family heme oxygenase	-
D4J22_RS06245	1255218..1257443	+	2226	WP_139547417.1	Hop family adhesin BabA	-
D4J22_RS06255	1258081..1258389	+	309	WP_139547091.1	hypothetical protein	Antitoxin
D4J22_RS06260	1258376..1258537	+	162	WP_139547092.1	type II toxin-antitoxin system YafQ family toxin	Toxin
D4J22_RS06265	1258504..1258695	+	192	WP_139547664.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
D4J22_RS06270	1259052..1260197	+	1146	WP_108169272.1	YbfB/YjiJ family MFS transporter	-
D4J22_RS06275	1260203..1261165	-	963	WP_139547418.1	GTP-binding protein	-
D4J22_RS06280	1261165..1261533	-	369	WP_139547419.1	hypothetical protein	-
D4J22_RS06285	1261580..1262461	-	882	WP_139547420.1	polysaccharide deacetylase	-
D4J22_RS06290	1262474..1263352	-	879	WP_139547421.1	carbon-nitrogen hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-52)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6130.37 Da
• Isoelectric Point: 10.1363

>T112822 WP_139547092.1 NZ_CP032905:1258376-1258537 [Helicobacter pylori]
MLIIETSKKFDKDLKILVKNGFDLKFLYKVVENLAKEQPLAPKYKDHPLKGAL

Nucleotide

• Length: 162 bp

>T112822 NZ_CP032905:1258376-1258537 [Helicobacter pylori]
ATGCTGATAATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGTTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGCTCCCAAATACAAAGACCACCCGCTCAAAGGCGCTTTAT
AA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 12192.01 Da
• Isoelectric Point: 10.2825

>AT112822 WP_139547091.1 NZ_CP032905:1258081-1258389 [Helicobacter pylori]
MPNTTNKDYTKYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNHL
CFKSVEDFKKHCENLRFKNADN

Nucleotide

• Length: 309 bp

>AT112822 NZ_CP032905:1258081-1258389 [Helicobacter pylori]
ATGCCAAACACCACCAACAAAGATTACACAAAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGACCAA
ACAAAAAAGAGCGTTAGAAAAATTGAAGGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAGCAC
TCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGATACCAAGAACCACCTT
TGTTTTAAAAGCGTAGAGGATTTTAAAAAACATTGTGAAAACTTAAGATTTAAAAATGCTGATAATTGA