Detailed information of TA system TA112821

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 664129..664585
• Replicon: chromosome
• Accession: NZ_CP032905
• Organism: Helicobacter pylori strain 26-A-EK1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D4J22_RS03395
• Protein ID: WP_139547092.1
• Coordinates: 664424..664585 (+)
• Length: 54 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D4J22_RS03390
• Protein ID: WP_139547091.1
• Coordinates: 664129..664437 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D4J22_RS03365	660180..660800	-	621	Protein_632	hypothetical protein	-
D4J22_RS03380	661410..663491	+	2082	WP_139547648.1	Hop family adhesin BabB	-
D4J22_RS03390	664129..664437	+	309	WP_139547091.1	hypothetical protein	Antitoxin
D4J22_RS03395	664424..664585	+	162	WP_139547092.1	type II toxin-antitoxin system YafQ family toxin	Toxin
D4J22_RS03400	664621..664767	+	147	WP_139547093.1	virulence protein	-
D4J22_RS03405	664980..665504	-	525	WP_001135604.1	acyl-CoA thioesterase	-
D4J22_RS03410	665644..666498	+	855	WP_139547094.1	SDR family oxidoreductase	-
D4J22_RS03415	666491..667471	+	981	WP_000921458.1	iron ABC transporter permease	-
D4J22_RS03420	667471..668238	+	768	WP_000242355.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-52)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6130.37 Da
• Isoelectric Point: 10.1363

>T112821 WP_139547092.1 NZ_CP032905:664424-664585 [Helicobacter pylori]
MLIIETSKKFDKDLKILVKNGFDLKFLYKVVENLAKEQPLAPKYKDHPLKGAL

Nucleotide

• Length: 162 bp

>T112821 NZ_CP032905:664424-664585 [Helicobacter pylori]
ATGCTGATAATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGTTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGCTCCCAAATACAAAGACCACCCGCTCAAAGGCGCTTTAT
AA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 12192.01 Da
• Isoelectric Point: 10.2825

>AT112821 WP_139547091.1 NZ_CP032905:664129-664437 [Helicobacter pylori]
MPNTTNKDYTKYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNHL
CFKSVEDFKKHCENLRFKNADN

Nucleotide

• Length: 309 bp

>AT112821 NZ_CP032905:664129-664437 [Helicobacter pylori]
ATGCCAAACACCACCAACAAAGATTACACAAAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGACCAA
ACAAAAAAGAGCGTTAGAAAAATTGAAGGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAGCAC
TCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGATACCAAGAACCACCTT
TGTTTTAAAAGCGTAGAGGATTTTAAAAAACATTGTGAAAACTTAAGATTTAAAAATGCTGATAATTGA