Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 16185..17385 Replicon chromosome
Accession NZ_CP032905
Organism Helicobacter pylori strain 26-A-EK1

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag D4J22_RS00065 Protein ID WP_033589652.1
Coordinates 16612..17385 (+) Length 258 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag D4J22_RS00060 Protein ID WP_033589651.1
Coordinates 16185..16622 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D4J22_RS00055 11932..15681 + 3750 WP_139546734.1 class I SAM-dependent DNA methyltransferase -
D4J22_RS00060 16185..16622 + 438 WP_033589651.1 SocA family protein Antitoxin
D4J22_RS00065 16612..17385 + 774 WP_033589652.1 hypothetical protein Toxin
D4J22_RS00070 17618..18805 - 1188 WP_139546735.1 transcription termination/antitermination protein NusA -
D4J22_RS00075 18969..20129 - 1161 WP_139546736.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(24-119)


Sequences

Toxin        


Download         Length: 258 a.a.        Molecular weight: 30154.21 Da        Isoelectric Point: 8.3838

>T112819 WP_033589652.1 NZ_CP032905:16612-17385 [Helicobacter pylori]
MEIKEEDKDKKLEEIIVSLCEKGDLSSQTDQIIKDLKEIYQGEYRHKYSKITTIILNSTRDREQAFMTLTQNIRTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLEDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEEKDKQENFFKKPKKPIFWFNLMVTILFVI
GFVGELHIIQRLVSKYL

Download         Length: 774 bp

>T112819 NZ_CP032905:16612-17385 [Helicobacter pylori]
ATGGAAATTAAAGAAGAAGATAAAGATAAAAAGCTAGAAGAAATTATTGTATCGCTGTGTGAAAAGGGGGATTTGTCTAG
CCAAACAGATCAAATCATCAAAGATCTCAAAGAAATCTATCAAGGAGAATACAGGCATAAATACTCAAAAATTACAACTA
TTATTTTAAATTCCACAAGGGATAGAGAGCAAGCCTTTATGACGCTCACACAAAATATAAGGACACTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAGAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAACAAACGCAATACATAACCATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGGAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTAAAAAACCTATTTTTTGGTTTAATCTGATGGTTACAATTCTATTTGTGATT
GGTTTTGTGGGAGAATTGCATATAATACAAAGATTAGTTTCTAAATATCTTTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17305.41 Da        Isoelectric Point: 6.1226

>AT112819 WP_033589651.1 NZ_CP032905:16185-16622 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKEFDKHLVSDDFEAWRYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLRKDELETINCSIEKCSKKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIRQEAKQTNGN

Download         Length: 438 bp

>AT112819 NZ_CP032905:16185-16622 [Helicobacter pylori]
ATGGTCAATACTTTGGAACTAGCAAAATATATTCTTAAGCATTCAAACAAAGAATTGAGTAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAGAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAGATACG
GGCCTGTTGCAAGGGAAGTGTATTATGAATACCGCAATTATGGTGCCAATTCAATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAAAAGATGAACTTGAAACCATCAATTGCTCCATAGAAAAATGCAGCAAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGCGCTTGGCATAAAAGCTTTAAAGAAGATAGAAAAGAAATCATTAGTAAAGATT
TGATCAGACAAGAAGCCAAACAAACAAATGGAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References