Detailed information of TA system TA112814

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 958774..959346
• Replicon: chromosome
• Accession: NZ_CP032902
• Organism: Helicobacter pylori strain 280-A-EK1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D4K40_RS04730
• Protein ID: WP_139521247.1
• Coordinates: 958774..958920 (-)
• Length: 49 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D4K40_RS04740
• Protein ID: WP_139520821.1
• Coordinates: 959035..959346 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D4K40_RS04710	955410..956177	-	768	WP_000242343.1	ABC transporter ATP-binding protein	-
D4K40_RS04715	956177..957157	-	981	WP_000921458.1	iron ABC transporter permease	-
D4K40_RS04720	957150..958004	-	855	WP_139520818.1	SDR family oxidoreductase	-
D4K40_RS04725	958144..958668	+	525	WP_139520819.1	acyl-CoA thioesterase	-
D4K40_RS04730	958774..958920	-	147	WP_139521247.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
D4K40_RS04735	958887..959048	-	162	WP_139520820.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
D4K40_RS04740	959035..959346	-	312	WP_139520821.1	hypothetical protein	Antitoxin
D4K40_RS04745	959975..962206	-	2232	WP_139520822.1	Hop family adhesin BabA	-
D4K40_RS04765	962791..963411	+	621	Protein_904	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (11-48)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 49 a.a.
• Molecular weight: 5832.90 Da
• Isoelectric Point: 10.6797

>T112814 WP_139521247.1 NZ_CP032902:c958920-958774 [Helicobacter pylori]
IQRPPAQRHFIKDFRECHLKPDLLLVYQIKKPKNTFFLVRLGSHNELF

Nucleotide

• Length: 147 bp

>T112814 NZ_CP032902:c958920-958774 [Helicobacter pylori]
ATACAAAGACCACCCGCTCAAAGGCACTTTATAAAAGATTTTAGGGAATGCCACTTAAAACCGGATTTATTGCTTGTCTA
TCAAATTAAAAAACCAAAAAACACCTTCTTTTTAGTAAGGTTAGGCAGTCATAACGAGTTGTTTTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12224.02 Da
• Isoelectric Point: 9.9773

>AT112814 WP_139520821.1 NZ_CP032902:c959346-959035 [Helicobacter pylori]
MPNTTAKKDCTQYSERQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALNLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCEDLRFKNADD

Nucleotide

• Length: 312 bp

>AT112814 NZ_CP032902:c959346-959035 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTGCACCCAATACAGCGAAAGACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAGGAAATCCAAGCTCAAAAGCAAAGGATTAAAAAAGCGCTCCAATTTAAAG
CGCTAAACCTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGATACCAAGAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAAAAGCATTGTGAAGACTTAAGATTTAAAAATGCTGATGATTGA