112812

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1007597..1008212 Replicon chromosome
Accession NZ_CP032900
Organism Helicobacter pylori strain 476-A-EK5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D4K94_RS05000 Protein ID WP_139542130.1
Coordinates 1007597..1007857 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D4K94_RS05005 Protein ID WP_139542131.1
Coordinates 1007838..1008212 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D4K94_RS04970 1003576..1004343 - 768 WP_000242353.1 ABC transporter ATP-binding protein -
D4K94_RS04975 1004343..1005323 - 981 WP_000921458.1 iron ABC transporter permease -
D4K94_RS04980 1005316..1006170 - 855 WP_139542127.1 SDR family oxidoreductase -
D4K94_RS04985 1006310..1006834 + 525 WP_120929831.1 acyl-CoA thioesterase -
D4K94_RS04990 1006880..1007218 - 339 WP_139542128.1 type II toxin-antitoxin system YafQ family toxin -
D4K94_RS04995 1007205..1007516 - 312 WP_139542129.1 hypothetical protein -
D4K94_RS05000 1007597..1007857 - 261 WP_139542130.1 type II toxin-antitoxin system YafQ family toxin Toxin
D4K94_RS05005 1007838..1008212 - 375 WP_139542131.1 hypothetical protein Antitoxin
D4K94_RS05010 1008696..1010930 - 2235 WP_139546476.1 Hop family adhesin BabA -
D4K94_RS05025 1011658..1012305 + 648 Protein_949 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10131.93 Da        Isoelectric Point: 9.0167

>T112812 WP_139542130.1 NZ_CP032900:c1007857-1007597 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILRKKEPLDPRFQDHALKGKWKPFRECHIKADILLVYLVKDDELVLLRLG
SHSELF

Download         Length: 261 bp

>T112812 NZ_CP032900:c1007857-1007597 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTCCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAAGAAAGAAAGAACCGCTAGATCCACGATTTCAAGATCATGCTCTAAAAGGCAAGTGGAAACCTT
TTAGGGAATGCCATATTAAAGCCGACATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTGTTTTGTTAAGACTAGGC
AGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14702.63 Da        Isoelectric Point: 8.4719

>AT112812 WP_139542131.1 NZ_CP032900:c1008212-1007838 [Helicobacter pylori]
MPNTTNKDYTQYSQRQLFNLIHQLEQKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCLG
RKIPNIQTQQAMRDVGNKETDLIVEDFSSYSDERKRALSVETQP

Download         Length: 375 bp

>AT112812 NZ_CP032900:c1008212-1007838 [Helicobacter pylori]
ATGCCAAACACCACCAACAAAGACTACACCCAATACAGCCAAAGACAGCTTTTTAATTTAATCCATCAATTAGAGCAAAA
AATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACTTTA
AGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTGTTTGGGG
CGCAAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGTAGGTAACAAAGAGACAGATTTGATTGTTGAGGATTT
TTCTAGTTACAGCGATGAAAGAAAAAGGGCTTTGAGTGTTGAAACTCAACCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References