Detailed information of TA system TA112810

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 1006880..1007516
• Replicon: chromosome
• Accession: NZ_CP032900
• Organism: Helicobacter pylori strain 476-A-EK5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D4K94_RS04990
• Protein ID: WP_139542128.1
• Coordinates: 1006880..1007218 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D4K94_RS04995
• Protein ID: WP_139542129.1
• Coordinates: 1007205..1007516 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D4K94_RS04970	1003576..1004343	-	768	WP_000242353.1	ABC transporter ATP-binding protein	-
D4K94_RS04975	1004343..1005323	-	981	WP_000921458.1	iron ABC transporter permease	-
D4K94_RS04980	1005316..1006170	-	855	WP_139542127.1	SDR family oxidoreductase	-
D4K94_RS04985	1006310..1006834	+	525	WP_120929831.1	acyl-CoA thioesterase	-
D4K94_RS04990	1006880..1007218	-	339	WP_139542128.1	type II toxin-antitoxin system YafQ family toxin	Toxin
D4K94_RS04995	1007205..1007516	-	312	WP_139542129.1	hypothetical protein	Antitoxin
D4K94_RS05000	1007597..1007857	-	261	WP_139542130.1	type II toxin-antitoxin system YafQ family toxin	-
D4K94_RS05005	1007838..1008212	-	375	WP_139542131.1	hypothetical protein	-
D4K94_RS05010	1008696..1010930	-	2235	WP_139546476.1	Hop family adhesin BabA	-
D4K94_RS05025	1011658..1012305	+	648	Protein_949	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12874.39 Da
• Isoelectric Point: 10.3101

>T112810 WP_139542128.1 NZ_CP032900:c1007218-1006880 [Helicobacter pylori]
MLIIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLAPKYKDHPLKGGLKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSRLFCKSPTPLITLKSTAQPTTPPLF

Nucleotide

• Length: 339 bp

>T112810 NZ_CP032900:c1007218-1006880 [Helicobacter pylori]
ATGCTGATAATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
GTATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGCTCCCAAATACAAAGACCACCCACTCAAAGGCGGTTTAA
AAGATTTTAGGGAATGCCACTTAAAACCGGATTTATTGCTTGTCTATCAAATCAAAAAACAAGAAAACACTCTCTTTTTA
GTAAGACTAGGCAGTCATAGCAGGCTGTTTTGTAAATCACCCACACCCCTTATAACGCTTAAATCAACCGCTCAACCAAC
TACCCCCCCCCTTTTTTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12308.08 Da
• Isoelectric Point: 10.0586

>AT112810 WP_139542129.1 NZ_CP032900:c1007516-1007205 [Helicobacter pylori]
MPNTTAKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILSRAEDTKNH
LCFKSIEDFKKHCENLRFKNADN

Nucleotide

• Length: 312 bp

>AT112810 NZ_CP032900:c1007516-1007205 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACCCAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAGGAAATCCAAGCTCAAAAGCAAAGGATTAAAAAAGCACTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGGTACACCATAGAAGAAGAGCGAGAAATCTTATCAAGGGCTGAAGATACCAAGAACCAC
CTTTGTTTTAAAAGCATAGAGGATTTTAAGAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATAATTGA