Detailed information of TA system TA112809

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 516567..517206
• Replicon: chromosome
• Accession: NZ_CP032899
• Organism: Helicobacter pylori strain 478-A-EK1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D4L20_RS02520
• Protein ID: WP_139549402.1
• Coordinates: 516567..516848 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D4L20_RS02525
• Protein ID: WP_139549403.1
• Coordinates: 516835..517206 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D4L20_RS02495	511610..512302	-	693	WP_108169276.1	restriction endonuclease	-
D4L20_RS02500	512304..513422	-	1119	WP_108288477.1	site-specific DNA-methyltransferase	-
D4L20_RS02505	513518..513883	+	366	WP_139549400.1	hypothetical protein	-
D4L20_RS02510	513883..514845	+	963	WP_139549401.1	GTP-binding protein	-
D4L20_RS02515	515030..516175	-	1146	WP_100979224.1	YbfB/YjiJ family MFS transporter	-
D4L20_RS02520	516567..516848	-	282	WP_139549402.1	type II toxin-antitoxin system YafQ family toxin	Toxin
D4L20_RS02525	516835..517206	-	372	WP_139549403.1	hypothetical protein	Antitoxin
D4L20_RS02535	517567..519801	-	2235	WP_139549404.1	Hop family adhesin BabA	-
D4L20_RS02540	520109..520864	-	756	WP_139549405.1	HugZ family heme oxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11145.18 Da
• Isoelectric Point: 9.5645

>T112809 WP_139549402.1 NZ_CP032899:c516848-516567 [Helicobacter pylori]
MLKIRHHIFFKKDFKKLVKNGFDDSVLNEVILTLRKKEPLDPRFQDHALKGKWKPFRECHIKPDVLLVYLVKDDELILLR
LGSHSELFCENYP

Nucleotide

• Length: 282 bp

>T112809 NZ_CP032899:c516848-516567 [Helicobacter pylori]
ATGCTGAAAATTAGGCATCATATCTTTTTCAAAAAAGACTTTAAAAAACTTGTTAAAAATGGGTTTGACGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAAAAAGAACCACTAGATCCACGATTTCAAGATCATGCCTTAAAGGGAAAGTGGA
AGCCTTTTAGGGAATGCCACATTAAGCCTGATGTTTTGCTTGTGTATTTAGTGAAAGATGATGAACTGATTTTGTTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTGTGAAAACTACCCATAA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 14541.51 Da
• Isoelectric Point: 7.8778

>AT112809 WP_139549403.1 NZ_CP032899:c517206-516835 [Helicobacter pylori]
MPNTTAKKDYTKYSEKQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GHEIPNIQTQQAMRDAVNGKNLETIEDFHAWANEIKKEVNAEN

Nucleotide

• Length: 372 bp

>AT112809 NZ_CP032899:c517206-516835 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCATGAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCGGTGAATGGCAAAAACTTAGAAACTATTGAAGA
CTTTCACGCATGGGCAAATGAAATAAAAAAGGAAGTGAATGCTGAAAATTAG