Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4791912..4792569 Replicon chromosome
Accession NZ_CP032897
Organism Enterobacter kobei strain WCHEK045523

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag D9T11_RS24615 Protein ID WP_014885136.1
Coordinates 4791912..4792322 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag D9T11_RS24620 Protein ID WP_010435322.1
Coordinates 4792303..4792569 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9T11_RS24595 4787906..4789639 - 1734 WP_023331239.1 single-stranded-DNA-specific exonuclease RecJ -
D9T11_RS24600 4789645..4790358 - 714 WP_121528248.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
D9T11_RS24605 4790387..4791283 - 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
D9T11_RS24610 4791385..4791906 + 522 WP_014885135.1 flavodoxin FldB -
D9T11_RS24615 4791912..4792322 - 411 WP_014885136.1 protein YgfX Toxin
D9T11_RS24620 4792303..4792569 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
D9T11_RS24625 4792864..4793844 + 981 WP_014885137.1 tRNA-modifying protein YgfZ -
D9T11_RS24630 4793929..4794588 - 660 WP_023331242.1 hemolysin III family protein -
D9T11_RS24635 4794855..4795586 + 732 WP_121528331.1 MurR/RpiR family transcriptional regulator -
D9T11_RS24640 4795703..4797136 + 1434 WP_014885140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T112807 WP_014885136.1 NZ_CP032897:c4792322-4791912 [Enterobacter kobei]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T112807 NZ_CP032897:c4792322-4791912 [Enterobacter kobei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTAATGCTCCACGGCCTGGTTGCGGC
CATCGTGTTACTCATGCCATGGCCCCTGAGCTATACGCCGCTGTGGCTGCTGTTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCTCGTCAGGGTGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTGGGCATGCCATGGATGCTCAACTCCGGCATGATGTTACGGTTACGCAATGTGGACGGCGGGCGTTG
CCAGCACTTGTGGCTGGCGGCTGACAGTATGGATGCTTCAGAATGGCGAGATCTGCGCCGGATGTTGTTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT112807 WP_010435322.1 NZ_CP032897:c4792569-4792303 [Enterobacter kobei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT112807 NZ_CP032897:c4792569-4792303 [Enterobacter kobei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGGCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References