Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4216938..4217643 Replicon chromosome
Accession NZ_CP032897
Organism Enterobacter kobei strain WCHEK045523

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag D9T11_RS21810 Protein ID WP_023326613.1
Coordinates 4217302..4217643 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag D9T11_RS21805 Protein ID WP_175540305.1
Coordinates 4216938..4217267 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9T11_RS21775 4212146..4213243 + 1098 WP_121528103.1 hypothetical protein -
D9T11_RS21780 4213342..4214235 + 894 WP_121528104.1 50S ribosome-binding GTPase -
D9T11_RS21785 4214521..4215198 + 678 WP_085017549.1 hypothetical protein -
D9T11_RS21790 4215297..4216115 + 819 WP_023326610.1 DUF945 domain-containing protein -
D9T11_RS21795 4216186..4216659 + 474 WP_023326611.1 DNA repair protein RadC -
D9T11_RS21800 4216675..4216896 + 222 WP_004129348.1 DUF987 domain-containing protein -
D9T11_RS21805 4216938..4217267 + 330 WP_175540305.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
D9T11_RS21810 4217302..4217643 + 342 WP_023326613.1 TA system toxin CbtA family protein Toxin
D9T11_RS21815 4217979..4218200 + 222 Protein_3952 transposase -
D9T11_RS21820 4218437..4219519 + 1083 WP_007851507.1 DNA-binding transcriptional repressor LacI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4197684..4239699 42015
- flank IS/Tn - - 4217979..4218269 290


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(8-108)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12904.95 Da        Isoelectric Point: 6.2133

>T112806 WP_023326613.1 NZ_CP032897:4217302-4217643 [Enterobacter kobei]
MNTLPAINQRAVQLCPSPVTIWQTLLTRLLEQHYGLALNDTPFGDESVIQEHIDAGITLVDTVNFLVEKYELVRIDRRAF
GWLEPSPYLRAVDILRMRRDMGLLRGCNHTAAM

Download         Length: 342 bp

>T112806 NZ_CP032897:4217302-4217643 [Enterobacter kobei]
ATGAATACTTTACCTGCAATAAACCAGCGGGCTGTTCAGTTATGCCCATCGCCCGTAACTATCTGGCAAACGTTGCTAAC
TCGTTTATTGGAACAACACTACGGGCTGGCGCTGAACGACACACCGTTCGGTGATGAAAGCGTCATTCAGGAACATATCG
ATGCCGGTATTACACTCGTTGATACTGTTAACTTTTTGGTGGAAAAGTACGAGCTGGTTCGTATCGACCGCAGGGCGTTT
GGCTGGTTGGAACCATCCCCATACTTGCGAGCTGTAGACATTCTGCGAATGCGTCGGGACATGGGGCTGTTGCGAGGCTG
CAACCACACTGCAGCAATGTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12268.06 Da        Isoelectric Point: 6.8413

>AT112806 WP_175540305.1 NZ_CP032897:4216938-4217267 [Enterobacter kobei]
VNDDTAEPWWGLNRNVIPCFGARLVQEGNRLHYLSDRASIIGLFNKADLLRLDQVFPVLLKQAELMLTSGELNPRHQHCV
TLYAKGLTCEADTLGSCGHVYISIYPTQR

Download         Length: 330 bp

>AT112806 NZ_CP032897:4216938-4217267 [Enterobacter kobei]
GTGAATGATGATACCGCTGAGCCCTGGTGGGGGCTGAATCGTAATGTCATTCCTTGTTTTGGTGCACGTCTGGTCCAGGA
AGGTAACCGCCTACATTATCTGTCTGACCGCGCCAGCATAATAGGCCTATTCAATAAAGCGGATTTGCTCCGTCTTGACC
AGGTATTTCCTGTTCTGCTGAAGCAGGCGGAGCTCATGCTTACCAGCGGCGAACTGAATCCCCGACACCAGCATTGCGTC
ACCCTCTATGCAAAGGGGTTGACCTGCGAAGCTGATACGCTGGGTTCCTGTGGTCACGTCTATATCTCCATTTATCCTAC
TCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References