Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 328271..328990 Replicon chromosome
Accession NZ_CP032897
Organism Enterobacter kobei strain WCHEK045523

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1B7K7P6
Locus tag D9T11_RS02805 Protein ID WP_023336519.1
Coordinates 328670..328990 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1B7K7N3
Locus tag D9T11_RS02800 Protein ID WP_023336520.1
Coordinates 328271..328636 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9T11_RS02765 324635..325069 + 435 WP_023336527.1 hypothetical protein -
D9T11_RS02770 325089..325892 + 804 WP_023336526.1 hypothetical protein -
D9T11_RS02780 326137..326577 + 441 WP_032645121.1 hypothetical protein -
D9T11_RS02785 326649..327470 + 822 WP_038859440.1 DUF945 domain-containing protein -
D9T11_RS02790 327539..328009 + 471 WP_023336522.1 DNA repair protein RadC -
D9T11_RS02795 328018..328239 + 222 WP_023336521.1 DUF987 domain-containing protein -
D9T11_RS02800 328271..328636 + 366 WP_023336520.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
D9T11_RS02805 328670..328990 + 321 WP_023336519.1 TA system toxin CbtA family protein Toxin
D9T11_RS02810 329132..330697 - 1566 WP_121527183.1 SIR2 family protein -
D9T11_RS02815 330738..330929 - 192 WP_121527184.1 toxin-antitoxin system HicB family antitoxin -
D9T11_RS02820 331065..331406 + 342 WP_121527185.1 SymE family type I addiction module toxin -
D9T11_RS02825 331466..332503 + 1038 WP_121527186.1 virulence RhuM family protein -
D9T11_RS02830 332500..332937 - 438 WP_121527187.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310702..339495 28793


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-104)

Antitoxin

Antitoxin CbeA

(18-115)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12166.88 Da        Isoelectric Point: 5.9559

>T112792 WP_023336519.1 NZ_CP032897:328670-328990 [Enterobacter kobei]
MHIPTVPATVTVSSRLSPVQIWQKLLTYLLEHHYGLTINDTPFSNDTAILEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWLTPLDVHRAQFTLGLKRS

Download         Length: 321 bp

>T112792 NZ_CP032897:328670-328990 [Enterobacter kobei]
ATGCATATTCCAACTGTACCGGCAACGGTGACGGTTTCGTCACGCCTATCTCCTGTCCAGATTTGGCAAAAACTATTAAC
GTATCTTTTAGAGCATCATTACGGCCTCACGATCAACGACACACCGTTCAGTAACGATACGGCGATTCTGGAACATATAG
AGGCGGGAGTGAATCTTACTGATGCTGTTAATTTCCTTGTAGAACGATTCGAGCTTGTGCGCATTGACCAGAAGGGTTTC
TCCTGGCAGGATCAAGAACCCTGGCTAACACCTTTGGATGTTCATCGGGCACAGTTCACCCTTGGCTTGAAACGCTCATA
A

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13481.16 Da        Isoelectric Point: 6.0592

>AT112792 WP_023336520.1 NZ_CP032897:328271-328636 [Enterobacter kobei]
MQSTTLSGTSAENASCFQWGLKRNITPCFGARLVQEGNRLYFLADRAGFNGSFSDEEALRLDQAFPLMMKQLEQMLTTGE
LDPSSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPWSALTR

Download         Length: 366 bp

>AT112792 NZ_CP032897:328271-328636 [Enterobacter kobei]
ATGCAGTCGACCACCTTATCCGGCACATCGGCGGAGAACGCATCCTGCTTTCAGTGGGGATTAAAACGTAATATCACGCC
ATGCTTCGGCGCTCGCCTGGTACAGGAAGGCAACCGCTTATACTTTCTGGCTGACCGGGCAGGATTTAATGGCTCATTCA
GTGACGAAGAAGCTTTGCGTCTGGACCAGGCATTTCCACTGATGATGAAACAGCTTGAGCAGATGCTGACCACTGGCGAG
CTTGATCCCAGCAGCCAGCACTGCGTCACACGGCATCACAACGGACTTACTTGTGAAGCTGACACTCTCGGCTCTCATGG
CTACGTTTACATCGCCATATATCCCTGGTCAGCTCTAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7K7P6

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7K7N3

References