Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3317674..3318509 Replicon chromosome
Accession NZ_CP032879
Organism Escherichia coli strain WCHEC000837

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J1YPH7
Locus tag D9N32_RS18405 Protein ID WP_029701676.1
Coordinates 3317674..3318051 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0K5N986
Locus tag D9N32_RS18410 Protein ID WP_021553056.1
Coordinates 3318141..3318509 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9N32_RS18380 3314041..3315579 - 1539 WP_001187196.1 lysine decarboxylation/transport transcriptional activator CadC -
D9N32_RS18390 3316328..3317170 - 843 WP_022645115.1 DUF4942 domain-containing protein -
D9N32_RS18395 3317255..3317449 - 195 WP_024181941.1 DUF957 domain-containing protein -
D9N32_RS27605 3317528..3317677 - 150 Protein_3083 hypothetical protein -
D9N32_RS18405 3317674..3318051 - 378 WP_029701676.1 TA system toxin CbtA family protein Toxin
D9N32_RS18410 3318141..3318509 - 369 WP_021553056.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
D9N32_RS18415 3318672..3318893 - 222 WP_000692345.1 DUF987 domain-containing protein -
D9N32_RS18420 3318958..3319434 - 477 WP_021553055.1 RadC family protein -
D9N32_RS18425 3319450..3319929 - 480 WP_001564060.1 antirestriction protein -
D9N32_RS18430 3320195..3321013 - 819 WP_001175165.1 DUF945 domain-containing protein -
D9N32_RS18435 3321103..3321336 - 234 WP_001278293.1 DUF905 family protein -
D9N32_RS18440 3321342..3322019 - 678 WP_001097302.1 hypothetical protein -
D9N32_RS18445 3322167..3322847 - 681 WP_029702103.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14066.04 Da        Isoelectric Point: 7.8045

>T112741 WP_029701676.1 NZ_CP032879:c3318051-3317674 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T112741 NZ_CP032879:c3318051-3317674 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13615.39 Da        Isoelectric Point: 7.0264

>AT112741 WP_021553056.1 NZ_CP032879:c3318509-3318141 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT112741 NZ_CP032879:c3318509-3318141 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1YPH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K5N986

References