Detailed information of TA system TA112699

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 6421288..6421793
• Replicon: chromosome
• Accession: NZ_CP032869
• Organism: Mucilaginibacter celer strain HYN0043

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HYN43_RS26760
• Protein ID: WP_119406924.1
• Coordinates: 6421539..6421793 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HYN43_RS26755
• Protein ID: WP_119406923.1
• Coordinates: 6421288..6421542 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYN43_RS26745	6417367..6418140	+	774	WP_119409142.1	lytic transglycosylase domain-containing protein	-
HYN43_RS26750	6418356..6421202	+	2847	WP_119406922.1	excinuclease ABC subunit UvrA	-
HYN43_RS26755	6421288..6421542	+	255	WP_119406923.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HYN43_RS26760	6421539..6421793	+	255	WP_119406924.1	Txe/YoeB family addiction module toxin	Toxin
HYN43_RS26765	6421837..6423624	+	1788	WP_119406925.1	DUF885 domain-containing protein	-
HYN43_RS26770	6423807..6424691	-	885	WP_119406926.1	UbiA family prenyltransferase	-
HYN43_RS26775	6424833..6425360	+	528	WP_162996645.1	YceI family protein	-
HYN43_RS26780	6425382..6426491	+	1110	WP_119406928.1	type III polyketide synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10094.58 Da
• Isoelectric Point: 9.3469

>T112699 WP_119406924.1 NZ_CP032869:6421539-6421793 [Mucilaginibacter celer]
VKIIFQSPGWEDYLYWQSTDKATLKKINSLIKEIERTPYEGAGKPEPLKHNLAGWWSRRINLEHRLIYRVEGDSVFILQC
RYHY

Nucleotide

• Length: 255 bp

>T112699 NZ_CP032869:6421539-6421793 [Mucilaginibacter celer]
GTGAAAATTATTTTTCAAAGTCCCGGATGGGAGGATTATCTCTATTGGCAAAGTACGGATAAGGCCACTTTAAAAAAGAT
CAATTCTCTTATCAAAGAAATAGAACGGACTCCTTATGAAGGAGCCGGCAAGCCTGAGCCTTTAAAGCACAATTTAGCGG
GATGGTGGTCGCGCCGTATTAATCTCGAGCATAGATTGATTTATAGAGTTGAGGGTGATTCTGTATTTATCCTCCAGTGC
AGATATCATTATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9792.08 Da
• Isoelectric Point: 4.8723

>AT112699 WP_119406923.1 NZ_CP032869:6421288-6421542 [Mucilaginibacter celer]
METTTYTTFRQQLKSFLDKVRNDHKPLIVTSTNAEDVVVMSKSDYESMEETFYLLKSPKNAARLLQGIEEYEKGLGQERK
LIEE

Nucleotide

• Length: 255 bp

>AT112699 NZ_CP032869:6421288-6421542 [Mucilaginibacter celer]
ATGGAAACGACAACGTATACAACATTCAGACAGCAGCTAAAATCGTTTTTAGATAAAGTGCGGAATGATCATAAACCACT
TATTGTAACCAGCACTAATGCGGAGGACGTAGTAGTGATGTCAAAATCTGATTACGAAAGCATGGAGGAAACTTTTTACC
TTTTAAAAAGTCCGAAAAATGCAGCAAGATTGCTTCAGGGGATCGAAGAATATGAAAAGGGTTTGGGTCAGGAAAGAAAA
CTGATCGAAGAGTGA