Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2354925..2355561 Replicon chromosome
Accession NZ_CP032867
Organism Bacillus subtilis subsp. subtilis strain N4-2

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag D9C20_RS12495 Protein ID WP_003156187.1
Coordinates 2355211..2355561 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G4NU32
Locus tag D9C20_RS12490 Protein ID WP_003225183.1
Coordinates 2354925..2355206 (+) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9C20_RS12470 2351284..2351883 - 600 WP_014478896.1 rhomboid family intramembrane serine protease -
D9C20_RS12475 2351978..2352343 + 366 WP_014478897.1 holo-ACP synthase -
D9C20_RS12480 2352509..2353525 + 1017 WP_003234282.1 outer membrane lipoprotein carrier protein LolA -
D9C20_RS12485 2353640..2354809 + 1170 WP_014478898.1 alanine racemase -
D9C20_RS12490 2354925..2355206 + 282 WP_003225183.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
D9C20_RS12495 2355211..2355561 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
D9C20_RS12500 2355677..2356501 + 825 WP_009966610.1 RsbT co-antagonist protein RsbRA -
D9C20_RS12505 2356506..2356871 + 366 WP_003225190.1 RsbT antagonist protein RsbS -
D9C20_RS12510 2356875..2357276 + 402 WP_014478899.1 serine/threonine-protein kinase RsbT -
D9C20_RS12515 2357288..2358295 + 1008 WP_014478900.1 phosphoserine phosphatase RsbU -
D9C20_RS12520 2358364..2358693 + 330 WP_003234298.1 anti-sigma factor antagonist RsbV -
D9C20_RS12525 2358690..2359172 + 483 WP_003234299.1 anti-sigma B factor RsbW -
D9C20_RS12530 2359138..2359926 + 789 WP_003246715.1 RNA polymerase sigma factor SigB -
D9C20_RS12535 2359926..2360525 + 600 WP_003246608.1 phosphoserine phosphatase RsbX -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-111)

Antitoxin

(12-45)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T112697 WP_003156187.1 NZ_CP032867:2355211-2355561 [Bacillus subtilis subsp. subtilis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

>T112697 NZ_CP032867:2355211-2355561 [Bacillus subtilis subsp. subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
CTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10546.92 Da        Isoelectric Point: 6.4708

>AT112697 WP_003225183.1 NZ_CP032867:2354925-2355206 [Bacillus subtilis subsp. subtilis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG

Download         Length: 282 bp

>AT112697 NZ_CP032867:2354925-2355206 [Bacillus subtilis subsp. subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCATATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8


Antitoxin

Source ID Structure
PDB 4ME7
AlphaFold DB G4NU32

References