Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 819202..819859 Replicon chromosome
Accession NZ_CP032841
Organism Enterobacter hormaechei strain C15117

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag D8M16_RS04005 Protein ID WP_017382887.1
Coordinates 819449..819859 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag D8M16_RS04000 Protein ID WP_003863437.1
Coordinates 819202..819468 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8M16_RS03980 814608..816041 - 1434 WP_023295383.1 6-phospho-beta-glucosidase BglA -
D8M16_RS03985 816158..816889 - 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
D8M16_RS03990 817156..817815 + 660 WP_003863433.1 hemolysin III family protein -
D8M16_RS03995 817927..818907 - 981 WP_022649306.1 tRNA-modifying protein YgfZ -
D8M16_RS04000 819202..819468 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
D8M16_RS04005 819449..819859 + 411 WP_017382887.1 protein YgfX Toxin
D8M16_RS04010 819861..820382 - 522 WP_015571793.1 flavodoxin FldB -
D8M16_RS04015 820484..821380 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
D8M16_RS04020 821409..822122 + 714 WP_121478608.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
D8M16_RS04025 822128..823861 + 1734 WP_121478609.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T112662 WP_017382887.1 NZ_CP032841:819449-819859 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T112662 NZ_CP032841:819449-819859 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGTAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT112662 WP_003863437.1 NZ_CP032841:819202-819468 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT112662 NZ_CP032841:819202-819468 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References