Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4641749..4643322 Replicon chromosome
Accession NZ_CP032839
Organism Aeromonas veronii strain FC951

Toxin (Protein)


Gene name hipA Uniprot ID A0A1Q8D8F8
Locus tag C0073_RS21500 Protein ID WP_075112288.1
Coordinates 4641749..4643068 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1Q8D8F6
Locus tag C0073_RS21505 Protein ID WP_042013334.1
Coordinates 4643068..4643322 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0073_RS21485 (C0073_021485) 4637670..4638434 + 765 WP_101530255.1 ATP-binding cassette domain-containing protein -
C0073_RS21490 (C0073_021490) 4638465..4639358 + 894 WP_101530270.1 ABC transporter substrate-binding protein -
C0073_RS21495 (C0073_021495) 4639355..4641337 + 1983 WP_101530254.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
C0073_RS21500 (C0073_021500) 4641749..4643068 - 1320 WP_075112288.1 type II toxin-antitoxin system HipA family toxin Toxin
C0073_RS21505 (C0073_021505) 4643068..4643322 - 255 WP_042013334.1 helix-turn-helix domain-containing protein Antitoxin
C0073_RS21510 (C0073_021510) 4643492..4643920 - 429 WP_075112289.1 DUF86 domain-containing protein -
C0073_RS21515 (C0073_021515) 4643913..4644362 - 450 WP_075112290.1 nucleotidyltransferase domain-containing protein -
C0073_RS21520 (C0073_021520) 4644810..4645439 + 630 WP_101530253.1 recombinase family protein -
C0073_RS21525 (C0073_021525) 4645424..4645747 - 324 WP_101530252.1 hypothetical protein -
C0073_RS23415 4645731..4645850 - 120 WP_225510977.1 hypothetical protein -
C0073_RS21530 (C0073_021530) 4646260..4646991 - 732 WP_052814528.1 SprT family zinc-dependent metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49366.38 Da        Isoelectric Point: 7.0150

>T112659 WP_075112288.1 NZ_CP032839:c4643068-4641749 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDGELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLFLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGIPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDAISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

>T112659 NZ_CP032839:c4643068-4641749 [Aeromonas veronii]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGCGCCCATCAGTTTCA
GTACCATGAGTCATGGCTGGCACAACCGGGCAGCCGTCCCATCTCACTTTCCATGCCATTGCGCCATCAGGCCTACCGGG
GCGATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGGAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACTCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGACGTTCCAGATGTCAGGCGAATCGACTACAAAGCACTTTCCGATGGCGAGCTCGAGCAGATTCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGAGCGCAAGAAAAGACAGCG
CTGCTCTTTCTCGATGGCCGTTGGTACTTGCCACTCAACGCAACGCCGACAACCCACATTATCAAACTCCCTATTGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTATACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGTCATGGAGGACCAGGGATCACTGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCGGCCACCGATGGCCATGCAAAGAACTTCTCGGTCTTTATT
GAACCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGCGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAATACGCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCGAAAGCTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGTGTTACCCAGCAATTGCCAGCGGGCTTCCCCGATGCCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGCTGGGATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9323.64 Da        Isoelectric Point: 7.9834

>AT112659 WP_042013334.1 NZ_CP032839:c4643322-4643068 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILASLELSLDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp

>AT112659 NZ_CP032839:c4643322-4643068 [Aeromonas veronii]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAACTCAATCCTGAGTCCACCAAGCTGGAAACCCTGT
TCAAGATCCTCGCATCACTCGAATTGTCACTGGACATCAAACCCCGCAATGAGTCATCCGAGAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q8D8F8

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8D8F6

References