112658

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 33722..34248 Replicon plasmid pINF237_04
Accession NZ_CP032837
Organism Klebsiella pneumoniae strain INF237

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag D9K64_RS28465 Protein ID WP_000323025.1
Coordinates 33722..34009 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag D9K64_RS28470 Protein ID WP_000534858.1
Coordinates 34009..34248 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9K64_RS28430 29218..30906 + 1689 WP_115233593.1 cloacin -
D9K64_RS28435 30916..31173 + 258 WP_000523382.1 cloacin immunity family protein -
D9K64_RS28440 31258..31407 + 150 WP_002193747.1 colicin release lysis protein -
D9K64_RS28445 31801..32376 + 576 WP_000904911.1 recombinase family protein -
D9K64_RS28455 32778..33246 + 469 Protein_43 cytoplasmic protein -
D9K64_RS28460 33492..33650 - 159 WP_014386184.1 type I toxin-antitoxin system Hok family toxin -
D9K64_RS28465 33722..34009 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
D9K64_RS28470 34009..34248 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
D9K64_RS28475 34534..35231 + 698 WP_181577867.1 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - vat 1..44993 44993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T112658 WP_000323025.1 NZ_CP032837:c34009-33722 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T112658 NZ_CP032837:c34009-33722 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT112658 WP_000534858.1 NZ_CP032837:c34248-34009 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT112658 NZ_CP032837:c34248-34009 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References