Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 112017..112660 | Replicon | plasmid pINF237_01-VP |
Accession | NZ_CP032834 | ||
Organism | Klebsiella pneumoniae strain INF237 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | A0A421H508 |
Locus tag | D9K64_RS26875 | Protein ID | WP_001044773.1 |
Coordinates | 112244..112660 (+) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | A0A060VSA5 |
Locus tag | D9K64_RS26870 | Protein ID | WP_001261277.1 |
Coordinates | 112017..112247 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
D9K64_RS26845 | 108107..108299 | + | 193 | Protein_102 | transposase | - |
D9K64_RS26850 | 108652..109437 | - | 786 | WP_040175061.1 | site-specific integrase | - |
D9K64_RS26855 | 109483..110004 | - | 522 | WP_121097595.1 | hypothetical protein | - |
D9K64_RS26860 | 110062..110453 | - | 392 | Protein_105 | hypothetical protein | - |
D9K64_RS26865 | 110490..111434 | - | 945 | WP_040175057.1 | hypothetical protein | - |
D9K64_RS26870 | 112017..112247 | + | 231 | WP_001261277.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
D9K64_RS26875 | 112244..112660 | + | 417 | WP_001044773.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
D9K64_RS26880 | 112719..113123 | - | 405 | Protein_109 | transposase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | - | clbI / iutA / iucD / iucC / iucB / iucA / rmpA / rmpA | 1..133713 | 133713 | |
- | flank | IS/Tn | - | - | 112677..113192 | 515 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15227.68 Da Isoelectric Point: 7.7805
>T112646 WP_001044773.1 NZ_CP032834:112244-112660 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPETVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK
VNKTYMLDTCICSFIMREQPETVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK
Download Length: 417 bp
>T112646 NZ_CP032834:112244-112660 [Klebsiella pneumoniae]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAACCGTCCTGAAACGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTGACGAATAATACAAGAGAATTTGAGCGGGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAACCGTCCTGAAACGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTGACGAATAATACAAGAGAATTTGAGCGGGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8899.03 Da Isoelectric Point: 4.5112
>AT112646 WP_001261277.1 NZ_CP032834:112017-112247 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVRELEIIREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL
MRTVSIFKNGNNRAIRLPRDLDFEGVRELEIIREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL
Download Length: 231 bp
>AT112646 NZ_CP032834:112017-112247 [Klebsiella pneumoniae]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCCCGTGATCTGGATTTTGAGGGGGTGAG
AGAGCTCGAGATCATCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGCTCATTCCTGGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCCCGTGATCTGGATTTTGAGGGGGTGAG
AGAGCTCGAGATCATCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGCTCATTCCTGGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A421H508 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A060VSA5 |