112643

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4334307..4334823 Replicon chromosome
Accession NZ_CP032833
Organism Klebsiella pneumoniae strain INF237

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag D9K64_RS21835 Protein ID WP_009309309.1
Coordinates 4334307..4334591 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag D9K64_RS21840 Protein ID WP_002886901.1
Coordinates 4334581..4334823 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9K64_RS21815 4329703..4330011 - 309 WP_040172617.1 PTS sugar transporter subunit IIB -
D9K64_RS29380 4330096..4330269 + 174 WP_040172618.1 hypothetical protein -
D9K64_RS21820 4330272..4331015 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
D9K64_RS21825 4331372..4333510 + 2139 WP_032446556.1 anaerobic ribonucleoside-triphosphate reductase -
D9K64_RS21830 4333839..4334303 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
D9K64_RS21835 4334307..4334591 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D9K64_RS21840 4334581..4334823 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
D9K64_RS21845 4334901..4336811 - 1911 WP_004152270.1 BglG family transcription antiterminator -
D9K64_RS21850 4336834..4337988 - 1155 WP_002886900.1 lactonase family protein -
D9K64_RS21855 4338055..4338795 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T112643 WP_009309309.1 NZ_CP032833:c4334591-4334307 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T112643 NZ_CP032833:c4334591-4334307 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT112643 WP_002886901.1 NZ_CP032833:c4334823-4334581 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT112643 NZ_CP032833:c4334823-4334581 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References