112631

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 561862..562516 Replicon chromosome
Accession NZ_CP032833
Organism Klebsiella pneumoniae strain INF237

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag D9K64_RS03005 Protein ID WP_004144731.1
Coordinates 562109..562516 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag D9K64_RS03000 Protein ID WP_002916312.1
Coordinates 561862..562128 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9K64_RS02975 557018..558451 - 1434 WP_040172235.1 6-phospho-beta-glucosidase -
D9K64_RS02980 558570..559298 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
D9K64_RS02985 559348..559659 + 312 WP_040172238.1 N(4)-acetylcytidine aminohydrolase -
D9K64_RS02990 559823..560482 + 660 WP_023342186.1 hemolysin III family protein -
D9K64_RS02995 560633..561616 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
D9K64_RS03000 561862..562128 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
D9K64_RS03005 562109..562516 + 408 WP_004144731.1 protein YgfX Toxin
D9K64_RS03010 562523..563044 - 522 WP_004144730.1 flavodoxin FldB -
D9K64_RS03015 563145..564041 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
D9K64_RS03020 564064..564777 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
D9K64_RS03025 564783..566516 + 1734 WP_115234329.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T112631 WP_004144731.1 NZ_CP032833:562109-562516 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T112631 NZ_CP032833:562109-562516 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT112631 WP_002916312.1 NZ_CP032833:561862-562128 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT112631 NZ_CP032833:561862-562128 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References