Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4744364..4744880 Replicon chromosome
Accession NZ_CP032831
Organism Klebsiella pneumoniae strain INF078

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag D9K63_RS23515 Protein ID WP_009309309.1
Coordinates 4744364..4744648 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag D9K63_RS23520 Protein ID WP_002886901.1
Coordinates 4744638..4744880 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9K63_RS23495 4739847..4740155 - 309 WP_019725542.1 PTS sugar transporter subunit IIB -
D9K63_RS29450 4740240..4740413 + 174 WP_019725541.1 hypothetical protein -
D9K63_RS23500 4740416..4741159 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
D9K63_RS23505 4741516..4743654 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
D9K63_RS23510 4743896..4744360 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
D9K63_RS23515 4744364..4744648 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D9K63_RS23520 4744638..4744880 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
D9K63_RS23525 4744958..4746868 - 1911 WP_004152270.1 BglG family transcription antiterminator -
D9K63_RS23530 4746891..4748045 - 1155 WP_002886900.1 lactonase family protein -
D9K63_RS23535 4748112..4748852 - 741 WP_032417761.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T112615 WP_009309309.1 NZ_CP032831:c4744648-4744364 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T112615 NZ_CP032831:c4744648-4744364 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT112615 WP_002886901.1 NZ_CP032831:c4744880-4744638 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT112615 NZ_CP032831:c4744880-4744638 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References