Detailed information of TA system TA112599

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1273003..1273528
• Replicon: chromosome
• Accession: NZ_CP032825
• Organism: Arcobacter cryaerophilus D2610

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ACRYD_RS06235
• Protein ID: WP_120987012.1
• Coordinates: 1273003..1273287 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A494T8Z2
• Locus tag: ACRYD_RS06240
• Protein ID: WP_066402160.1
• Coordinates: 1273271..1273528 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACRYD_RS06215	1268282..1269514	+	1233	WP_066163967.1	glucose-6-phosphate isomerase	-
ACRYD_RS06220	1269518..1270429	+	912	WP_120987003.1	AEC family transporter	-
ACRYD_RS10430	1270486..1271091	-	606	WP_120987006.1	hypothetical protein	-
ACRYD_RS06230	1271143..1272873	-	1731	WP_120987009.1	UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)	-
ACRYD_RS06235	1273003..1273287	-	285	WP_120987012.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ACRYD_RS06240	1273271..1273528	-	258	WP_066402160.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
ACRYD_RS06245	1273682..1274788	-	1107	WP_120987015.1	UDP-N-acetylbacillosamine transaminase	-
ACRYD_RS06250	1274781..1275386	-	606	WP_120987018.1	UDP-N-acetylbacillosamine N-acetyltransferase	-
ACRYD_RS06255	1275383..1275979	-	597	WP_120987020.1	undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase	-
ACRYD_RS06260	1275985..1277202	-	1218	WP_120987023.1	glycosyltransferase family 4 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-76)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11320.20 Da
• Isoelectric Point: 10.3690

>T112599 WP_120987012.1 NZ_CP032825:c1273287-1273003 [Arcobacter cryaerophilus D2610]
MSYFLDFHPKALKEWKNLNQSLKIQFHKKLKERLENPRVSKDKLSGYENIYKIKLRSSGFRLAYEVKDLEIIVYVVSVGK
RENNKVYENLKDRI

Nucleotide

• Length: 285 bp

>T112599 NZ_CP032825:c1273287-1273003 [Arcobacter cryaerophilus D2610]
ATGAGCTACTTTCTTGATTTTCATCCAAAAGCTTTGAAAGAGTGGAAAAATCTTAATCAATCTTTAAAGATACAGTTTCA
TAAAAAACTAAAAGAACGACTTGAAAATCCAAGAGTGTCAAAAGATAAATTAAGTGGCTATGAAAATATTTATAAAATAA
AATTAAGAAGTTCTGGTTTTAGACTTGCTTATGAGGTTAAAGATTTGGAGATAATAGTATATGTTGTAAGTGTTGGTAAG
AGAGAAAATAATAAAGTGTATGAAAATTTGAAAGATAGAATATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9673.10 Da
• Isoelectric Point: 4.2696

>AT112599 WP_066402160.1 NZ_CP032825:c1273528-1273271 [Arcobacter cryaerophilus D2610]
MQPILANYTASITELKKSPTQLLKDAGDEAIAILNHNVASAYLVPASLYEKMMEVMDDYYLSKELEERLKDNEKPIRVEL
DELLS

Nucleotide

• Length: 258 bp

>AT112599 NZ_CP032825:c1273528-1273271 [Arcobacter cryaerophilus D2610]
ATGCAACCAATATTAGCAAACTATACAGCAAGTATAACCGAACTTAAAAAATCACCAACTCAACTACTCAAAGATGCTGG
AGATGAAGCAATAGCTATACTCAATCATAATGTAGCTTCTGCTTATTTAGTTCCAGCAAGTTTGTATGAAAAGATGATGG
AAGTTATGGATGATTACTACCTAAGCAAAGAGCTTGAGGAAAGACTTAAAGACAATGAAAAACCAATAAGAGTAGAGCTA
GATGAGCTACTTTCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A494T8Z2