Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 471790..472267 Replicon chromosome
Accession NZ_CP032821
Organism Staphylococcus aureus strain JDFM SA01

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag D5S13_RS02410 Protein ID WP_000052076.1
Coordinates 472079..472267 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag D5S13_RS02405 Protein ID WP_001059690.1
Coordinates 471790..472050 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5S13_RS02370 (D5S13_00463) 467183..467899 - 717 WP_000150019.1 type I 3-dehydroquinate dehydratase -
D5S13_RS02375 (D5S13_00464) 468047..468469 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
D5S13_RS02380 (D5S13_00465) 468868..469362 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
D5S13_RS02385 (D5S13_00466) 469517..470134 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
D5S13_RS02390 (D5S13_00467) 470207..470788 - 582 WP_001140697.1 histidine phosphatase family protein -
D5S13_RS02395 (D5S13_00468) 471013..471249 + 237 WP_000368687.1 hypothetical protein -
D5S13_RS02400 (D5S13_00469) 471246..471449 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
D5S13_RS02405 (D5S13_00470) 471790..472050 + 261 WP_001059690.1 hypothetical protein Antitoxin
D5S13_RS02410 (D5S13_00471) 472079..472267 + 189 WP_000052076.1 hypothetical protein Toxin
D5S13_RS02415 (D5S13_00472) 472455..473024 + 570 WP_001106652.1 lipoprotein N-acylation protein LnsA -
D5S13_RS02420 (D5S13_00473) 473112..473396 + 285 WP_001004394.1 hypothetical protein -
D5S13_RS02425 473458..473683 + 226 Protein_481 hypothetical protein -
D5S13_RS02430 (D5S13_00475) 474177..474377 - 201 WP_001059082.1 cold-shock protein -
D5S13_RS02435 (D5S13_00476) 474734..475420 - 687 WP_263259068.1 thermonuclease family protein -
D5S13_RS02440 (D5S13_00477) 475761..476231 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(12-128)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T112581 WP_000052076.1 NZ_CP032821:472079-472267 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T112581 NZ_CP032821:472079-472267 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT112581 WP_001059690.1 NZ_CP032821:471790-472050 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT112581 NZ_CP032821:471790-472050 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References